Infection of immunosuppressed mice with the abomasal nematode parasite of ruminants, Haemonchus contortus

International Journal for Parasitology
D B Adams

Abstract

Infective larvae of Haemonchus contortus established in mice either immunosuppressed with the corticosteroid, dexamethasone, or the cytotoxic drug, cyclophosphamide, or treated with the histamine H2 inhibitor, cimetidine. Infections persisted for as long as the immunosuppressive treatment (7 days) and growth of larvae was similar to that seen in sheep. Virtually no larvae survived in untreated mice. Accordingly, it would appear that adaptive immunity is an important barrier against primary infection by H. contortus in mice and is a determinant of host-range for this parasite. Antibody raised in either sheep or mice against soluble extracts of adult H. contortus precipitated with different but overlapping sets of worm antigens. This suggests that the unique antigens recognized by the mouse compared with the sheep are crucial for the rapid protective responses which prevent primary infection.

References

Sep 1, 1976·Journal of Helminthology·G W Hutchinson, J O Slocombe
Jun 1, 1976·International Journal for Parasitology·L F Le JambreK M Dash
Nov 1, 1989·International Journal for Parasitology·D B AdamsR G Windon
May 1, 1989·International Journal for Parasitology·B M WaglandD Ouwerkerk
Jan 1, 1988·Parasite Immunology·F Bolas-FernandezD Wakelin
Mar 21, 1981·Lancet·M E OsbandR McCaffrey
Sep 15, 1981·Journal of Molecular Biology·D Kolodrubetz, R Schleif
Aug 1, 1964·Experimental Parasitology·P H SILVERMAN, K R PODGER

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Citations

Jun 28, 2007·Ecology Letters·James S ClarkMike Wolosin

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