Infection of young adult mice with dengue virus type 2

Transactions of the Royal Society of Tropical Medicine and Hygiene
S BoonpucknavigV Boonpucknavig

Abstract

Young adult female mice, five to six weeks old, were injected intraperitoneally with 2.5 x 10(6.3) LD50 of dengue-2 virus, New Guinea C strain. The mice were killed on day 1, 2, 3, 4, 5, 6, 7, 10, 14, 21, 28, and 35 respectively. By means of the immunofluorescent antibody technique, viral antigen appeared as irregular granules in the reticuloendothelial cells of liver, lymph nodes and spleen of infected mice on the first day after inoculation and then diminished. From the fifth to sixth day of infection dengue antigen appeared again as homogeneous staining in the cytoplasm of single or groups of mononuclear cells in the lymphatic sinuses only. Later, by the third week of infection, dengue antigen could be seen in the mononuclear cells located in the marginal zone of lymphoid follicle of the spleen, the pattern of staining changing to bright spherical granules. At the same time, the deposition of immune complexes (composed of dengue antigen, mouse gamma and beta 1C globulin) could be seen in the renal glomeruli of infected mice. Serum antibody to dengue virus was found at low levels, being maximal on the 14th day after infection. Dengue virus was not isolated from the sera or from the infected organs. Granulomatous inflammation ...Continue Reading

References

Sep 1, 1975·American Journal of Clinical Pathology·S BoonpucknavigS Nimmannitya
Nov 1, 1969·The American Journal of Tropical Medicine and Hygiene·S B HalsteadS Rohitayodhin
Dec 26, 1968·The New England Journal of Medicine·G E BurchR S Sohal
Dec 1, 1967·The American Journal of Medicine·M M Jensen
Jan 1, 1968·Transactions of the Royal Society of Tropical Medicine and Hygiene·T Burke
Feb 1, 1957·The Journal of Experimental Medicine·A M PRINCE, H S GINSBERG
Jul 1, 1959·Virology·R M FRANKLIN, P M BREITENFELD
Oct 3, 2013·The Journal of the Royal College of Physicians of Edinburgh·R Hilton

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Citations

Aug 24, 2004·Antiviral Research·Nathalie CharlierJohan Neyts
Apr 27, 2004·Neuroreport·Gilma Sánchez-BurgosCelso Ramos
Jan 8, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Carla PagliariMaria Irma Seixas Duarte
Jul 16, 2008·Seminars in Nephrology·Emerson Q Lima, Mauricio L Nogueira
Jan 1, 2014·Journal of Medical Virology·Viviana Martínez-BetancurMarlén Martínez-Gutierrez
Oct 4, 2006·Virology·Nikos VasilakisScott C Weaver
Jun 18, 2005·Virology·M V PaesO M Barth
Dec 20, 2014·Virus Research·Sasiprapa KhunchaiPa-Thai Yenchitsomanus
Feb 13, 2007·Memórias do Instituto Oswaldo Cruz·Ortrud Monika BarthHermann Gonçalves Schatzmayr
Sep 2, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marciano Viana PaesAda Maria de Barcelos Alves
Dec 15, 2019·Viruses·Feroza BegumUpasana Ray
Oct 1, 2012·Clinical Kidney Journal·Muhammad A M KhalilSyed A Hussain
May 14, 2018·Cellular Signalling·Gopinathan Pillai SreekanthThawornchai Limjindaporn

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