Infection Strategies of Bacterial and Viral Pathogens through Pathogen-Human Protein-Protein Interactions.

Frontiers in Microbiology
Saliha D Durmuş TekirKutlu Ö Ülgen

Abstract

Since ancient times, even in today's modern world, infectious diseases cause lots of people to die. Infectious organisms, pathogens, cause diseases by physical interactions with human proteins. A thorough analysis of these interspecies interactions is required to provide insights about infection strategies of pathogens. Here we analyzed the most comprehensive available pathogen-human protein interaction data including 23,435 interactions, targeting 5,210 human proteins. The data were obtained from the newly developed pathogen-host interaction search tool, PHISTO. This is the first comprehensive attempt to get a comparison between bacterial and viral infections. We investigated human proteins that are targeted by bacteria and viruses to provide an overview of common and special infection strategies used by these pathogen types. We observed that in the human protein interaction network the proteins targeted by pathogens have higher connectivity and betweenness centrality values than those proteins not interacting with pathogens. The preference of interacting with hub and bottleneck proteins is found to be a common infection strategy of all types of pathogens to manipulate essential mechanisms in human. Compared to bacteria, virus...Continue Reading

Citations

Mar 22, 2013·Bioinformatics·Saliha Durmuş TekirKutlu Ö Ülgen
Jul 3, 2013·Bioinformatics·Meghana KshirsagarJudith Klein-Seetharaman
Aug 14, 2013·Current Opinion in Microbiology·Roya Zoraghi, Neil E Reiner
Apr 29, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chérif ChetouhiDavid G Biron
Apr 29, 2015·Frontiers in Microbiology·Saliha DurmuşReinhard Guthke
Mar 12, 2015·Frontiers in Microbiology·Esmaeil NouraniSaliha Durmuş
Feb 24, 2015·Frontiers in Microbiology·Meghana KshirsagarJudith Klein-Seetharaman
Mar 5, 2015·PLoS Computational Biology·Vesna MemiševićAnders Wallqvist
Oct 23, 2016·Journal of Virological Methods·Nicole L McLellanMarc B Habash
May 21, 2016·Parasite Immunology·J de la FuenteC Maritz-Olivier
Jan 17, 2017·Nature Communications·Núria Crua AsensioMarc Torrent Burgas
Feb 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pia WentkerJulio Vera
May 27, 2016·Molecular BioSystems·Anita HorvatićMangesh Bhide
Aug 12, 2015·Briefings in Bioinformatics·Archana PanBuvaneswari Shanmugham
Dec 6, 2019·Frontiers in Oncology·Emine Guven-MaiorovRuth Nussinov
Oct 21, 2014·Expert Review of Proteomics·Tao Cui, Zheng-Guo He
Oct 13, 2017·PLoS Computational Biology·Emine Guven-MaiorovRuth Nussinov
Jun 25, 2020·Cells·Valentina Dallacasagrande, Katherine A Hajjar
May 21, 2013·Journal of Proteome Research·Lokesh P TripathiKenji Mizuguchi

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Software Mentioned

IntAct
BiNGO
MATLAB BGL package
MATLAB
Reactome
DIP
Mint
PHISTO

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