Infection with a periodontal pathogen increases mononuclear cell adhesion to human aortic endothelial cells

Atherosclerosis
G A RothE Lalla

Abstract

As a link between periodontal infections and an increased risk for vascular disease has been demonstrated, we assessed the ability of the Gram-negative periodontal pathogen Porphyromonas gingivalis to modulate properties of endothelial cells linked to inflammation and proatherogenic pathways. Primary human aortic endothelial cells (HAEC) were infected with either P. gingivalis strain 381 or its non-invasive fimbriae-deficient mutant, DPG3, and incubated with U-937 monocytes, or Jurkat T cells. P. gingivalis-infected HAEC demonstrated significantly increased adhesion of immune cells compared to non-infected cells or those infected with DPG3. Heat-killed bacteria had no effect on mononuclear cell adhesion and P. gingivalis LPS had only a minimal effect. P. gingivalis infection significantly increased HAEC expression of VCAM-1, ICAM-1 and E-selectin, and enhanced production of IL-6, IL-8 and MCP-1. These data demonstrate that live invasive P. gingivalis 381 elicits a pro-atherogenic response in HAEC.

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Citations

Jul 30, 2009·Odontology·Takako Nakajima, Kazuhisa Yamazaki
Jun 10, 2009·The American Journal of Chinese Medicine·Sun Mi HwangHo Sub Lee
Feb 24, 2010·Journal of Dental Research·S JanketT E Van Dyke
Feb 21, 2009·Journal of Periodontology·C F SantosM C O Salgado
Sep 3, 2009·Journal of Periodontology·S Reid LesterRoger B Johnson
May 19, 2010·Journal of Periodontology·Yoshihiro ShimazakiYoshihisa Yamashita
Apr 2, 2011·Journal of Periodontology·Elena FigueroMariano Sanz
Nov 5, 2011·Journal of Periodontology·Lícia Bezerra CavalcanteRaquel M Scarel-Caminaga
May 3, 2013·Journal of Periodontology·Leticia ReyesAnn Progulske-Fox
Jan 1, 2010·Journal of Oral Microbiology·Shaneen J LeishmanPauline J Ford
Feb 15, 2014·TheScientificWorldJournal·Xin-Fang LeongSrijit Das
Jan 19, 2016·Experimental and Molecular Pathology·Dimitry A ChistiakovYuri V Bobryshev
Jan 24, 2009·Kidney International·Abhijit V KshirsagarRonald J Falk
Jul 12, 2011·Trends in Cardiovascular Medicine·HaiYing LiJunYing Miao
Mar 31, 2009·Medical Hypotheses·ZhiWen YaoZhiQing Chen
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Feb 1, 2011·FEMS Immunology and Medical Microbiology·Tomomi HashizumeMasafumi Yamamoto
Apr 27, 2007·FEMS Microbiology Letters·Georg A RothEvanthia Lalla

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