Abstract
The role of human herpesvirus (HHV)-8 in the pathogenesis of multiple myeloma and its pre-malignant state of monoclonal gammopathy is unclear. HHV-8 is transmitted by organ transplantation, representing a unique model with which to investigate primary HHV-8 infection. The authors studied the incidence of clonal gammopathy in renal transplant recipients and correlated it with previous and recent HHV-8 infection. Clonal gammopathy was observed in 31 of 162 (19%) HHV-8-seronegative patients, in 5 of 17 (29%) HHV-8-seropositive patients, and in 9 of 24 (38%) HHV-8 seroconverters within 5 years after transplantation. Gammopathy was often transient, and no progression to myeloma was observed. Two patients with persistent gammopathy developed B-cell lymphoma. In a logistic regression model, HHV-8 serostatus of the graft recipient was significantly associated with subsequent development of gammopathy, with a relative risk (RR) of 1.9 and a 95% confidence interval (CI) of 0.5 to 6.4 for an HHV-8-seropositive recipient and an RR of 2.9 and a 95% CI of 1.01 to 8.0 for seroconverters as compared with baseline (HHV-8 seronegative). Other significant variables were cytomegalovirus (CMV) serostatus and the intensity of immunosuppression (RR o...Continue Reading
References
Dec 20, 1990·The New England Journal of Medicine·L J SwinnenR I Fisher
Apr 1, 1990·Transplantation·A M FischerA Fischer
Jun 1, 1989·Transplantation·C A PollockA G Sheil
Nov 1, 1985·The Journal of Infectious Diseases·M HoR L Hardesty
Oct 1, 1985·Clinical Immunology and Immunopathology·J RadlL C Paul
May 4, 1995·The New England Journal of Medicine·P S Moore, Y Chang
Dec 18, 1993·Lancet·G Opelz, R Henderson
Oct 26, 1996·Lancet·G R SimpsonP S Moore
Dec 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J PasswegH A Bock
Jun 20, 1997·Science·M B RettigJ R Berenson
Nov 5, 1998·The New England Journal of Medicine·N RegameyP Erb
Dec 31, 1998·Virus Research·S J OlsenY Chang
Nov 7, 1999·Transplantation·J D Pirsch
Dec 10, 1999·Transplantation·C V PayaJ S Bromberg
Oct 30, 1999·Nihon rinsho. Japanese journal of clinical medicine·F Mizuno
Mar 11, 2000·British Journal of Haematology·P Brousset Delsol
Mar 18, 2000·Leukemia & Lymphoma·S A StoneM J Stone
Jul 11, 2000·British Journal of Haematology·R BeckH Einsele
Nov 9, 2000·The New England Journal of Medicine·M LuppiG Torelli
Aug 25, 2001·Blood·A LemoineB Debuire
Jan 17, 2003·Leukemia·S HermouetJ W Casey
Apr 15, 2003·Nature Medicine·Patrizia BarozziGiuseppe Torelli
Citations
Jul 17, 2008·International Journal of Hematology·Mohammad Hadi SadeghianMohammad Reza Keramati
Feb 1, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R R Razonable
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J LeUNKNOWN AST Infectious Diseases Community of Practice
Oct 18, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Alessandra GaliotoPaolo Angeli
Jan 28, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R R RazonableUNKNOWN AST Infectious Diseases Community of Practice
Nov 15, 2019·Transplantation Direct·Marie-France GagnonBernard Lemieux