Infection with influenza a virus leads to flu antigen-induced cutaneous anaphylaxis in mice

The Journal of Investigative Dermatology
S M GrunewaldKlaus J Erb

Abstract

It is well established, that viral infections may trigger urticaria or allergic asthma; however, as viral infections induce T helper 1 polarized responses, which lead to the inhibition of T helper 2 cell development, the opposite would be plausible. We wanted to investigate how viral infections may mediate allergic symptoms in a mouse model; therefore, we infected BALB/C mice with influenza A virus intranasally. Histologic analyses of lung sections and bronchoalveolar lavages were performed. In addition, cells from the mediastinal lymph nodes were restimulated in vitro to analyze which types of cytokines were induced by the flu infection. Furthermore, flu-specific antibody titers were determined and local anaphylaxis was measured after rechallenge with flu antigen. We found that airways inflammation consisted predominately of macrophages and lymphocytes, whereas only a few eosinophils were observed. interferon-gamma but no interleukin-4 and little interleukin-5 could be detected in the culture supernatants from in vitro restimulated T cells from the draining lymph nodes. The antibody response was characterized by high levels of virus-specific IgG2a, IgG2b, and IgG1 and, surprisingly, low levels of virus-specific IgE antibodies....Continue Reading

References

Aug 4, 1994·Nature·H C OettgenP Leder
Feb 1, 1997·The Journal of Allergy and Clinical Immunology·M K Church, F Levi-Schaffer
Apr 1, 1997·Thorax·J M Corne, S T Holgate
Apr 1, 1998·Archives of Dermatology·P MortureuxA Taïeb
Nov 18, 1998·The Journal of Allergy and Clinical Immunology·S SuzukiT Okubo
Feb 19, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D R O'Donnell, P J Openshaw
Apr 13, 1999·The Journal of Allergy and Clinical Immunology·S M van SchaikR C Welliver
Jan 13, 2000·Current Opinion in Immunology·B Homey, A Zlotnik
Feb 25, 2000·International Archives of Allergy and Immunology·P ParronchiE Maggi
Mar 18, 2000·The Journal of Dermatology·M SakuraiM Takigawa
Aug 10, 2000·The Journal of Allergy and Clinical Immunology·J E Gern, W W Busse
Oct 6, 2000·Current Opinion in Pediatrics·M R Lester, L C Schneider
Dec 5, 2000·Current Opinion in Immunology·U HerzK Erb
May 8, 2001·International Archives of Allergy and Immunology·A NeldeS M Grunewald

❮ Previous
Next ❯

Citations

Jun 16, 2005·International Archives of Allergy and Immunology·Claudia Milena Trujillo-VargasKlaus Joseph Erb
Mar 31, 2011·International Journal of Medical Sciences·Tamar A Smith-NorowitzMartin H Bluth
Aug 27, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C M Trujillo-VargasK J Erb
Dec 1, 2005·Scandinavian Journal of Immunology·A DavidssonK A Brokstad
Mar 14, 2013·Clinical and Experimental Immunology·J LappalainenK K Eklund
Jun 6, 2009·American Journal of Clinical Dermatology·Evangelo Frigas, Miguel A Park
Jul 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qizhi YaoChangyi Chen
Apr 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gisela WohllebenKlaus J Erb
Mar 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy C GrahamJoshua J Obar
Mar 9, 2021·Frontiers in Cellular and Infection Microbiology·Ashleigh R Murphy-Schafer, Silke Paust

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.