Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Tongmin WangA Chong

Abstract

Infections and TLR signals at the time of transplantation have been shown to prevent the induction of tolerance, but their effect on allografts after tolerance has been established is unclear. We here report that infection with Listeria monocytogenes precipitated the loss of tolerance and the MyD88- and T cell-dependent rejection of accepted cardiac allografts in mice. This loss of tolerance was associated with increases in the numbers of graft-infiltrating macrophages and dendritic cells, as well as CD4(+)FoxP3(-) and CD8(+) T cells. Rejection was also associated with increased numbers of graft-infiltrating alloreactive as well as Listeria-reactive IFNgamma-producing T cells. Rejection of the established grafts required both IL-6 and IFNss, cytokines produced during acute Listeria infection. However, IL-6 and IFNss alone, even when present at higher concentrations than during Listeria infection, were insufficient to break tolerance, while the combination of IL-6 and IFNss was sufficient to break tolerance. These and in vitro observations that IL-6 but not IFNss enhanced T cell proliferation while IFNss but not IL-6 enhanced IFNgamma production support a hypothesis that these cytokines play nonredundant roles. In conclusion, th...Continue Reading

References

Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·N S KenyonC Ricordi
Nov 9, 2000·Immunology Today·J D Farrar, K M Murphy
Feb 13, 2001·Vaccine·I JulkunenS Matikainen
Jun 19, 2002·The Journal of Experimental Medicine·Luis GracaHerman Waldmann
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anna ValujskikhPeter S Heeger
Jan 18, 2003·Science·Chandrashekhar Pasare, Ruslan Medzhitov
Dec 3, 2003·Nature Medicine·Zihao WuLaurence A Turka
Oct 2, 2004·Nature Reviews. Immunology·Eric G Pamer
Mar 23, 2005·Immunity·Jason D FontenotAlexander Y Rudensky
Apr 6, 2005·The Journal of Experimental Medicine·Iris LeeWayne W Hancock
Oct 13, 2005·International Journal of Pharmaceutics·Ikuko YamaneYoshinobu Takakura
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas B ThornleyDale L Greiner
Aug 11, 2006·Arthritis Research & Therapy·Tadamitsu Kishimoto
Sep 15, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L ChenA Chong
Dec 15, 2006·Gene Therapy·H Herweijer, J A Wolff
Sep 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Sophie BrouardMinnie Sarwal
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katsunori TanakaNader Najafian
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas B ThornleyDale L Greiner
Jan 25, 2008·The New England Journal of Medicine·Tatsuo KawaiDavid H Sachs
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tongmin WangAnita S Chong
Jul 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paige M PorrettLaurence A Turka
Jul 26, 2008·The Journal of Clinical Investigation·Marc Martínez-LlordellaAlberto Sánchez-Fueyo
Sep 10, 2008·International Journal of Antimicrobial Agents·Ronald Feld
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Audrea M BurnsAnita S Chong
Mar 26, 2009·The Pediatric Infectious Disease Journal·Maria R MoroJoseph B Domachowske
Apr 10, 2009·Journal of the American Society of Nephrology : JASN·Hua Shen, Daniel R Goldstein
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luqiu ChenMaria-Luisa Alegre
Aug 18, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·V C de VriesR J Noelle

❮ Previous
Next ❯

Citations

Dec 7, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ivana R FerrerMandy L Ford
Jan 19, 2011·Transplantation·Lloyd J A D'OrsognaFrans H J Claas
Jun 22, 2012·Journal of Transplantation·Marcos V SilvaRosana R M Corrêa
May 26, 2012·Nature Reviews. Immunology·Anita S Chong, Maria-Luisa Alegre
Nov 15, 2011·Transplantation Reviews·Bhavana PriyadharshiniMichael A Brehm
Dec 4, 2010·Transplantation Reviews·Emily B AhmedAnita S Chong
Jul 31, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R G Gill
Apr 1, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E B AhmedA S Chong
Feb 13, 2014·Immunological Reviews·Ephraim J Fuchs
Feb 13, 2014·Immunological Reviews·Anita S Chong, Maria-Luisa Alegre
Feb 13, 2014·Immunological Reviews·Martin H Oberbarnscheidt, Fadi G Lakkis
Feb 13, 2014·Immunological Reviews·Daniel N MoriDaniel R Goldstein
Jul 21, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R G Gill
Feb 18, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J A Fishman
Jul 8, 2015·Nature Communications·Michelle L MillerAnita S Chong
Jun 21, 2016·The Journal of Clinical Investigation·Yuk Man LeiMaria-Luisa Alegre
Jun 21, 2016·The Journal of Clinical Investigation·Mandy L Ford
Jun 9, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J S YoungA S Chong
Apr 30, 2016·Transplant International : Official Journal of the European Society for Organ Transplantation·Wen-Tao HePing Zhou
Aug 16, 2016·Journal of Reproductive Immunology·Ângela C CrespoTamara Tilburgs
Apr 20, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M L MillerM-L Alegre
Jan 10, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M K NelsenR G Gill
May 10, 2017·The Journal of Clinical Investigation·Leonardo V RiellaMaria-Luisa Alegre
Nov 28, 2017·Current Transplantation Reports·Anil Dangi, Xunrong Luo
Jun 26, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kortney A RobinsonGilles Benichou
Aug 23, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Lei ZhangXunrong Luo
Dec 1, 2017·Current Opinion in Organ Transplantation·Maria-Luisa Alegre
Jan 20, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Victoria E RaelMaria-Luisa Alegre
Feb 15, 2019·Cellular & Molecular Immunology·Pawan K GuptaMaria-Luisa Alegre
Oct 9, 2013·Nature Reviews. Nephrology·Mandy L FordThomas C Pearson
Aug 2, 2013·Transplantation·Maria-Luisa AlegreAnita S Chong
Jul 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Shuangjin YuXunrong Luo
Aug 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Satona TanakaDaniel Kreisel
Nov 4, 2017·Annual Review of Pathology·Eric Perkey, Ivan Maillard
May 26, 2018·Microbiome·Christine M McIntoshMaria-Luisa Alegre
Jan 11, 2020·Frontiers in Immunology·Henrieta PapúchováTamara Tilburgs
Sep 21, 2019·Immunological Reviews·Shuangjin YuXunrong Luo
Dec 1, 2017·Current Transplantation Reports·Michelle L MillerMaria-Luisa Alegre
Nov 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Michelle L MillerMaria-Luisa Alegre
Feb 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel R Goldstein
Jul 12, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Lu LiuLisha Mou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
C H CookC G Orosz
American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
L ChenA Chong
© 2021 Meta ULC. All rights reserved