Infection with Trypanosoma cruzi restricts the repertoire of parasite-specific CD8+ T cells leading to immunodominance

The Journal of Immunology : Official Journal of the American Association of Immunologists
Fanny TzelepisM M Rodrigues

Abstract

Interference or competition between CD8(+) T cells restricted by distinct MHC-I molecules can be a powerful means to establish an immunodominant response. However, its importance during infections is still questionable. In this study, we describe that following infection of mice with the human pathogen Trypanosoma cruzi, an immunodominant CD8(+) T cell immune response is developed directed to an H-2K(b)-restricted epitope expressed by members of the trans-sialidase family of surface proteins. To determine whether this immunodominance was exerted over other non-H-2K(b)-restricted epitopes, we measured during infection of heterozygote mice, immune responses to three distinct epitopes, all expressed by members of the trans-sialidase family, recognized by H-2K(b)-, H-2K(k)-, or H-2K(d)-restricted CD8(+) T cells. Infected heterozygote or homozygote mice displayed comparably strong immune responses to the H-2K(b)-restricted immunodominant epitope. In contrast, H-2K(k)- or H-2K(d)-restricted immune responses were significantly impaired in heterozygote infected mice when compared with homozygote ones. This interference was not dependent on the dose of parasite or the timing of infection. Also, it was not seen in heterozygote mice immun...Continue Reading

References

May 1, 1983·Infection and Immunity·N Yoshida
Apr 26, 1995·Journal of Immunological Methods·G R BenavidesR L Tarleton
Oct 18, 2000·The Journal of Experimental Medicine·R M KedlP Marrack
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M SkoberneG Geginat
Dec 4, 2001·Nature Immunology·Ross M KedlPhilippa Marrack
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasmine BelkaidDavid Sacks
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hans Christian ProbstMaries F van den Broek
Aug 3, 2002·Nature Reviews. Molecular Cell Biology·Stewart Shuman
Dec 24, 2002·Current Opinion in Immunology·Ross M KedlPhilippa Marrack
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lai-Yu KwokDirk Schlüter
Feb 15, 2003·Trends in Parasitology·Moriya Tsuji, Fidel Zavala
Oct 2, 2003·Trends in Parasitology·Rick L Tarleton
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angus T StockFrancis R Carbone
Sep 14, 2004·Immunological Reviews·Alexandre Morrot, Fidel Zavala
Sep 14, 2004·Immunological Reviews·Diana Martin, Rick Tarleton
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M Mansour HaeryfarJonathan W Yewdell
Jun 9, 2005·The Journal of Experimental Medicine·Ian TesterHugo R Rosen
Jul 16, 2005·Science·Najib M El-SayedBjörn Andersson
Aug 30, 2005·Trends in Parasitology·Felipe Kierszenbaum
Dec 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teng-Chih YangJonathan L Bramson
Jan 25, 2006·International Immunology·María Cecilia AlbaredaMiriam Postan
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Richard A WillisPhilippa C Marrack
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sylvie BertholetDavid Sacks
Aug 22, 2007·The Journal of Experimental Medicine·Wolfgang KastenmullerIngo Drexler

❮ Previous
Next ❯

Citations

Jun 23, 2009·Expert Review of Vaccines·Silvia Inés CazorlaEmilio Luis Malchiodi
Sep 16, 2010·Expert Reviews in Molecular Medicine·Caroline JunqueiraRicardo T Gazzinelli
Jul 30, 2014·The Journal of Infectious Diseases·Mauricio Martins Rodrigues, Jonatan Ersching
Jul 30, 2014·The Journal of Infectious Diseases·Christian Teh-PootEric Dumonteil
Jun 16, 2016·Frontiers in Immunology·Anne GeigerPhilippe Holzmuller
Oct 3, 2020·Parasitology Research·Ruben D Arroyo-OlarteBertha Espinoza
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Julio ScharfsteinRodrigo Correa-Oliveira
Jul 8, 2011·Clinical Microbiology Reviews·Antonio R L TeixeiraNadjar Nitz
Nov 25, 2011·Proceedings of the National Academy of Sciences of the United States of America·Caroline JunqueiraRicardo T Gazzinelli
Jan 19, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·G A DosReis
Sep 24, 2009·Memórias do Instituto Oswaldo Cruz·Mauricio M RodriguesJosé Ronnie Vasconcelos
Aug 12, 2014·Mediators of Inflammation·José M ÁlvarezMaria Regina D'Império Lima
Mar 31, 2018·PLoS Neglected Tropical Diseases·Augusto E BivonaEmilio L Malchiodi
Sep 11, 2018·Frontiers in Immunology·Gonzalo R AcevedoKarina A Gómez
Feb 16, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gonzalo R AcevedoKarina A Gómez
Aug 18, 2020·Parasite Immunology·Damián Pérez-MazliahMichael D Lewis
Jan 29, 2010·The Journal of Biological Chemistry·Leonardo Freire-de-LimaAdriane R Todeschini
Jan 15, 2010·Journal of Cellular and Molecular Medicine·Silvia Beatriz BoscardinAriel Mariano Silber
Aug 28, 2012·BMC Infectious Diseases·Paola LassoConcepción Judith Puerta
Aug 12, 2014·Mediators of Inflammation·Fernando Dos Santos VirgilioJosé Ronnie Vasconcelos
Feb 3, 2016·Frontiers in Immunology·Mariana S CardosoDaniella C Bartholomeu
Sep 20, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paola LassoAdriana Cuéllar
Jun 15, 2019·Scientific Reports·Frederico Alisson-SilvaAdriane R Todeschini
Jun 3, 2011·Cellular Microbiology·Daniel F HoftIsaac G Sakala
Jun 10, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles S RosenbergRick L Tarleton
Nov 4, 2011·Human Vaccines·Israel Quijano-Hernandez, Eric Dumonteil
Jul 30, 2019·PLoS Neglected Tropical Diseases·Camila Pontes FerreiraJosé Ronnie Carvalho Vasconcelos
Oct 15, 2019·Trends in Parasitology·Eva V Acosta RodríguezAdriana Gruppi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Angel PadillaRick L Tarleton
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology
Yang-Bo TangXia Jin
The Journal of Immunology : Official Journal of the American Association of Immunologists
Joshua S WoodworthSamuel M Behar
© 2021 Meta ULC. All rights reserved