Infections: a double-edge sword in autoimmunity

Current Opinion in Rheumatology
Oded Shamriz, Yehuda Shoenfeld

Abstract

Infections play a role in the pathogenesis of autoimmune diseases (AID). Several bacterial and viral pathogens play a double role, as both inducers and inhibitors of AID. In this review, we will present current evidence and discuss different aspects of this notion. Infectors that both inhibit and induce AID include Helicobacter pylori, Klebsiella pneumoniae, hepatitis B virus, group B Coxsackieviruses, Epstein-Barr virus and Lymphocytic choriomeningitis virus. Numerous AID are affected by infections, including polyarteritis nodosa, inflammatory bowel disease, and type 1 diabetes. Some pathogens, such as group B Coxsackieviruses, may induce and inhibit the development of the same AID. This reveals a complex role of infections in autoimmunity pathogenesis. Elucidating the exact role of each pathogen on each specific AID is important, as this will enable evaluating the manipulation of these infections in the treatment of AID.

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Citations

Sep 7, 2019·Therapeutic Advances in Musculoskeletal Disease·George E Fragoulis, Nikolaos V Sipsas
Apr 11, 2018·Current Opinion in Rheumatology·Yahel SegalYehuda Shoenfeld
Jan 16, 2020·World Journal of Diabetes·Adebola Matthew GiwaAbdel Rahim A Hamad
Dec 11, 2020·Microbial Pathogenesis·Supriya Rajendra RananawareDipankar Nandi
Sep 13, 2020·Helicobacter·Rinaldo PellicanoAntonio Gasbarrini

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