Infections after orthotopic liver transplantation

Journal of Clinical and Experimental Hepatology
Mark Pedersen, Anil Seetharam

Abstract

Opportunistic infections are a leading cause of morbidity and mortality after orthotopic liver transplantation. Systemic immunosuppression renders the liver recipient susceptible to de novo infection with bacteria, viruses and fungi post-transplantation as well to reactivation of pre-existing, latent disease. Pathogens are also transmissible via the donor organ. The time from transplantation and degree of immunosuppression may guide the differential diagnosis of potential infectious agents. However, typical systemic signs and symptoms of infection are often absent or blunted after transplant and a high index of suspicion is needed. Invasive procedures are often required to procure tissue for culture and guide antimicrobial therapy. Antimicrobial prophylaxis reduces the incidence of opportunistic infections and is routinely employed in the care of patients after liver transplant. In this review, we survey common bacterial, fungal, and viral infections after orthotopic liver transplantation and highlight recent developments in their diagnosis and management.

References

Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J C ArnoldR Williams
Apr 11, 1991·The New England Journal of Medicine·R H Rubin
Aug 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G SteinhoffR Pichlmayr
Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·I LautenschlagerJ Ahonen
Apr 16, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MarteliusI Lautenschlager
Nov 25, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·N Singh, D L Paterson
Jul 26, 2000·Transplantation·I LautenschlagerK Höckerstedt
Dec 20, 2000·The Journal of Infectious Diseases·J C MendezC V Paya
Jun 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C V Paya
Mar 1, 2002·The Journal of Infection·J C GrahamR Freeman
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Per LjungmanCarlos Paya
Apr 20, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kelly W BurakMichael R Charlton
May 10, 2002·The Journal of Infectious Diseases·Frank J JenkinsAngela Liegey-Dougall
Aug 1, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Raymund R Razonable, Carlos V Paya
Oct 4, 2002·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·I LautenschlagerK Höckerstedt
Nov 9, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jesús FortúnMiguel García
Jan 22, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·G WuS Kusne
May 30, 2003·The New England Journal of Medicine·Martha IwamotoUNKNOWN West Nile Virus in Transplant Recipients Investigation Team
May 25, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Karen Doucette, Jay A Fishman
Jun 3, 2004·The Lancet Infectious Diseases·Monique A S H Mennink-KerstenPaul E Verweij
Jun 29, 2004·World Journal of Gastroenterology : WJG·Liang-Hui Gao, Shu-Sen Zheng
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J GavaldaUNKNOWN RESITRA (Spanish Network for Research on Infection in Transplantation)
Nov 18, 2005·Journal of Hepatology·Jean-François Dufour, Martin F Fey
Nov 30, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Janis E Blair, Shimon Kusne
Dec 31, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shimon Kusne, Janis E Blair
Apr 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·W K KremersT M Habermann
Apr 22, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Mario CrucianiPaolo Grossi
Sep 8, 2006·European Journal of Gastroenterology & Hepatology·Patrizia BurraSavina Maria Luciana Aversa
Dec 29, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Norah A TerraultUNKNOWN A2ALL Study Group
Mar 30, 2007·The British Journal of Radiology·M S DhillonJ Olliff
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Makoto OsawaMichiaki Mishima
Jun 1, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·David G KochAdrian Reuben

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Citations

May 6, 2015·Journal of Clinical and Experimental Hepatology·Sahaj Rathi, Radha K Dhiman
May 21, 2016·International Journal of Clinical Practice·M-L ZhangS-S Zheng
Oct 11, 2016·Molecular Therapy. Methods & Clinical Development·Giuseppe RonzittiFederico Mingozzi
Dec 13, 2016·Transplantation·Lawrence LauJames Bailey
Jun 26, 2017·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yuhko SuzukiHikaru Kume
Jan 24, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Cristiana LaiciStefano Faenza
Feb 11, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·B LavezzoF G De Rosa
Nov 1, 2018·Current Opinion in Infectious Diseases·Efthymia I MatthaiouJoe L Hsu
Jan 31, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nicolas Weiss, Dominique Thabut
Feb 2, 2016·Current Protocols in Toxicology·Jamie C DeWittVictor J Johnson
Apr 27, 2018·Langenbeck's Archives of Surgery·Cornelius Johannes BuschMarcel Hochreiter
Jul 28, 2018·Pediatric Transplantation·Seishiro NodomiSouichi Adachi
Feb 24, 2017·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·A KramerJ C Harnoss
Dec 24, 2019·Journal of Surgical Case Reports·Ryan A Helmick, Uchenna A Agbim
Aug 4, 2020·World Journal of Transplantation·Mahmoud El-BendaryMohamed Abdel-Wahab
Feb 11, 2021·Viral Immunology·Lin-Lin ZhangFeng Fang
Jul 25, 2021·British Dental Journal·Andreea Cristiana DidilescuHendrik Simon Brand
May 20, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mercedes MartinezMark R Deneau
Sep 24, 2021·Frontiers in Physiology·Rishikesan KamaleswaranDaniel G Maluf

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