Infections Caused by Carbapenemase-Producing Klebsiella pneumoniae: Microbiological Characteristics and Risk Factors

Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease
Hongying PanYunqing Qiu

Abstract

The spread of carbapenemase-producing Klebsiella pneumoniae (CPKP) worldwide is a serious problem. This retrospective, matched case-control, parallel study in a tertiary teaching hospital analyzed the microbiological and clinical characteristics of CPKP infection, focusing on the risk factors for carbapenem resistance and patient mortality. The hospital department with the highest incidence of CPKP infections was the intensive care unit. All CPKP strains examined were positive for blakpc-2, and 84.8% of CPKP were ST11. Hypervirulent phenotype was identified in 22.7% of the patients with CPKP, with these strains displaying a high incidence of positivity for entB, ybtS, and iutA. Multivariate conditional logistic regression analysis demonstrated that Pitt bacteremia score >4, prior stomach tube, continuous renal replacement therapy (CRRT), and previous carbapenem exposure were associated with CPKP infection. Higher albumin concentration and use of cephalosporins after diagnosis were strong prognostic factors for crude 28-day mortality. Further, high APACHE II score, CRRT, use of carbapenems after diagnosis, and bacteremia were risk factors for crude in-hospital mortality. CPKP isolates showed clonal spread and were resistant to m...Continue Reading

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Citations

Jun 26, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Lisha ShenHua Zhou
Aug 9, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Dan-Dan WeiYang Liu
Jun 24, 2020·Antimicrobial Resistance and Infection Control·Jiaying ZhuJinju Duan
Jan 14, 2022·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Si ChenYang Liu

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Methods Mentioned

BETA
lavage
PCR

Software Mentioned

SPSS

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