Infections in 92 splenectomized patients with Hodgkin's disease. A clinical review

The American Journal of Medicine
S C SchimpffP H Wiernik

Abstract

Infections that occurrred in 92 previously untreated patients with Hodgkin's disease were reviewed from the time of laprotomy and splenectomy. Pneumonias occurred in nine patients with urinary tract infections in twelve during the immediate postoperative period. Severe bacterial infections did not occur in any patients during initial radiation therapy, adjuvant chemotherapy (stages I through IIIA), initial intensive chemotherapy (stages IIIB and IV) or during remission. Severe infections occurred in eight profoundly granulocytopenic patients with recurrent Hodgkin's disease. Streptococcus (Diplococcus) pneumoniae and Hemophilus spp infections were distinctly uncommon during the remission period. Herpes zoster, however, was very common developing in 22 of 92 (24 per cent) patients. Predisposing factors to herpes zoster included sex (female more than male), therapy (radiation plus chemotherapy more than chemotherapy alone), and age (less than 30 years of age more often than 30 to 50 years of age). Severe infection was uncommon in these patients except in ascociation with specific predisposing factors such as the immediate postoperative state of prolonged granulocytopenia associated with recurrent Hodgkin's disease or its therapy....Continue Reading

Citations

Jun 1, 1976·The Journal of Clinical Investigation·G W KingA F LoBuglio
Jan 1, 1986·Medical and Pediatric Oncology·K M Rowland, A Murthy
May 1, 1983·The British Journal of Surgery·A KeelP F Jones
Jan 1, 1977·American Journal of Hematology·W Krivit
Apr 17, 1979·Klinische Wochenschrift·D Huhn, W Wilmanns
Sep 1, 1991·The British Journal of Surgery·R J HoldsworthA Cuschieri
Jan 1, 1983·Cancer Investigation·F Rosner, M H Zarrabi
Oct 7, 1976·The New England Journal of Medicine·R R ChilcoteD Hammond
May 1, 1987·The British Journal of Surgery·A A DawsonD J King
Mar 1, 1980·British Journal of Haematology·C J RutherfordA I Barnett
Oct 27, 2006·Nucleosides, Nucleotides & Nucleic Acids·J Stewart Cameron
May 1, 1986·Scandinavian Journal of Haematology·M BaccaraniS Tura
Aug 1, 1978·Cancer·D L SweetJ E Ultmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.