Abstract
Laboratory services contribute to the management of patients with neurosurgical infections in a variety of ways and, in so doing, increase the likelihood of a favourable outcome. Microbiology laboratories and clinical microbiologists are able to confirm the diagnosis, identify the causative agents and facilitate optimal antimicrobial therapy. Other pathology specialties perform investigations which help neurosurgeons to differentiate between postoperative aseptic and bacterial meningitis, these disease processes being indistinguishable on clinical grounds. A broad range of variables have been evaluated to date, but only the lactate and interleukin-1beta concentrations in cerebrospinal fluid have been shown to have sufficiently high sensitivities and specificities to be useful for this purpose. In preliminary studies measurement of the serum C-reactive protein concentration has been shown to be an effective criterion for monitoring the response to antibacterial therapy in patients with spinal extradural abscesses, postoperative discitis, brain abscesses and subdural empyemas, thereby enabling patients to be treated successfully with courses of these drugs that are markedly shorter than those currently recommended.
References
Oct 1, 1989·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P S RolandB E Mickey
Apr 1, 1989·Clinical Otolaryngology and Allied Sciences·J H Dempster
Nov 1, 1988·Journal of Neurosurgery·D RossV Pons
Jul 1, 1974·Journal of Neurosurgery·P W CarmelB M Stein
Dec 1, 1983·Journal of Neurosurgery·R H Britt, D R Enzmann
Oct 1, 1983·Neurosurgery·C E RawlingsR Francis
Jan 1, 1993·The Pediatric Infectious Disease Journal·X Sáez-Llorens, F Lagrutta
Jan 1, 1993·The Pediatric Infectious Disease Journal·R Dagan
Jan 1, 1996·Acta neurochirurgica·A B Jamjoom
Jun 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D GendrelC Bohuon
Aug 1, 1997·The Pediatric Infectious Disease Journal·D L Jaye, K B Waites
Aug 5, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B BylJ P Thys
Aug 5, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S L LeibW Zimmerli
Aug 18, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A ViallonJ C Bertrand
Feb 10, 2000·Critical Care Medicine·L F López-CortésJ Pachón
Jul 8, 2000·British Journal of Neurosurgery
Jul 13, 2000·Critical Care Medicine·S SchwarzW Hacke
Nov 1, 1949·Archives of Neurology and Psychiatry·I J JACKSON