Infections in renal transplant patients treated with cyclosporine or azathioprine

Scandinavian Journal of Infectious Diseases
W T van DorpL C Paul

Abstract

The incidence and severity of infectious complications were retrospectively investigated in 80 renal transplant patients who had been selected randomly to receive either cyclosporine (CsA) or azathioprine (Aza) in combination with low doses of corticosteroids. In the first 3 months, the incidence of infections was twice as high in the Aza-treated patients (p less than 0.05) which was due to an increase of predominantly minor infections. This increased incidence of infections was related to the increased number of anti-rejection treatments in the Aza-treated group. The types of infections were not different between the 2 treatment groups nor did the incidence of CMV infections differ. In the CsA-treated group, patients were randomly assigned at 3 months after transplantation to either continuation of CsA therapy or conversion to Aza. After conversion a small but not significant increase in predominantly minor infections was observed, which may be attributable to increased doses of corticosteroids given during the conversion. We conclude that in the first 3 months following transplantation, CsA therapy is associated with significantly less infections than Aza therapy; following conversion of CsA to Aza at 3 months only a small in...Continue Reading

References

Oct 22, 1987·The New England Journal of Medicine·D R SnydmanA S Levey
May 8, 1986·The New England Journal of Medicine·UNKNOWN Canadian Multicentre Transplant Study Group
May 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D E SutherlandJ S Najarian
Sep 13, 1984·The New England Journal of Medicine·B D MyersM Perlroth
Nov 1, 1982·Reviews of Infectious Diseases·H MasurW T Stubenbord

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Citations

Aug 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·Y J KraatC A Bruggeman
Dec 1, 1990·Transplant International : Official Journal of the European Society for Organ Transplantation·W T van DorpF J van der Woude
Nov 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·G A Bruyn, R van Furth
Nov 1, 1991·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C d'IvernoisJ Y Lacut
Aug 19, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hiroko KunitakeLiliana Bordeianou
Jul 22, 2017·The Cochrane Database of Systematic Reviews·Krishna M KarpeGiles D Walters

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