PMID: 9420218Jan 7, 1998Paper

Infectious cellular load in human immunodeficiency virus type 1 (HIV-1)-infected individuals and susceptibility of peripheral blood mononuclear cells from their exposed partners to non-syncytium-inducing HIV-1 as major determinants for HIV-1 transmission in homosexual couples

Journal of Virology
H BlaakH Schuitemaker

Abstract

To study risk factors for homosexual transmission of human immunodeficiency virus type 1 (HIV-1), we compared 10 monogamous homosexual couples between whom transmission of HIV-1 had occurred with 10 monogamous homosexual couples between whom HIV-1 transmission had not occurred despite high-risk sexual behavior. In the group of individuals who did not transmit virus, peripheral cellular infectious load was lower and the CD4+ T-cell counts were higher than in the group of transmitters. HIV-1 RNA levels in serum did not differ between transmitters and nontransmitters. Compared with peripheral blood mononuclear cells (PBMC) from normal healthy blood donors, 8 of 10 nonrecipients and only 3 of 8 recipients had PBMC with reduced susceptibility to in vitro infection with non-syncytium-inducing (NSI) HIV-1 variants isolated from either their respective partners or an unrelated individual. No difference in susceptibility was observed for infection with a syncytium-inducing variant. Among the individuals who had PBMC with reduced susceptibility, five nonrecipients and one recipient had PBMC that were equally or even less susceptible to NSI variants than PBMC that had low susceptibility and that were derived from healthy blood donors that...Continue Reading

References

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Feb 1, 1989·The Journal of Infectious Diseases·L BelecP M Martin
Aug 1, 1994·AIDS·C F Caceres, G J van Griensven
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Citations

Sep 23, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jacques ReynesPierre Corbeau
Nov 13, 2008·AIDS Research and Human Retroviruses·Emily C SpeelmonM Juliana McElrath
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fransje A KoningHanneke Schuitemaker
Jul 14, 2006·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marie NguyenGianfranco Pancino
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L LopalcoA G Siccardi
Jun 8, 1999·Annual Review of Immunology·E A BergerJ M Farber
Jul 24, 1998·Trends in Microbiology·A M de Roda Husman, H Schuitemaker
Sep 27, 2006·Virology·Kevin OlivieriDavid Camerini

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