Infectious clones of novel lineage 1 and lineage 2 West Nile virus strains WNV-TX02 and WNV-Madagascar.

Journal of Virology
Mehul S SutharMichael Gale

Abstract

We report the generation of West Nile virus (WNV) infectious clones for the pathogenic lineage 1 Texas-HC2002 and nonpathogenic lineage 2 Madagascar-AnMg798 strains. The infectious clones exhibited biological properties similar to those of the parental virus isolates. We generated chimeric viruses and found that viral factors within the structural and nonstructural regions of WNV-TX contribute to the control of type I interferon defenses. These infectious clones provide new reagents to study flavivirus immune regulation and pathogenesis.

References

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Citations

Jan 11, 2013·Journal of Virology·Daphne Y MaEdward A Clark
Dec 5, 2012·PLoS Pathogens·Hilario J RamosMichael Gale
Nov 2, 2013·Viruses·Kendra M Quicke, Mehul S Suthar
Jul 16, 2014·Archives of Virology·Katherine L HussmannBrenda L Fredericksen
Jun 13, 2014·The Journal of General Virology·Katherine L HussmannBrenda L Fredericksen
Mar 15, 2015·Current Opinion in Virology·Daphne Y Ma, Mehul S Suthar
Oct 30, 2016·Current Opinion in Virology·Michaela U Gack, Michael S Diamond
Jan 17, 2013·Nature Reviews. Microbiology·Mehul S SutharMichael Gale
Sep 20, 2019·Journal of Virology·Matthew G ZimmermanMehul S Suthar
Jun 4, 2020·Vaccines·Marie-France Martin, Sébastien Nisole
Jul 8, 2020·Virologica Sinica·Yan GuoCheng-Feng Qin

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