Infectious complications in adult acute lymphoblastic leukemia (ALL): experience at one single center

Leukemia & Lymphoma
M OffidaniP Leoni

Abstract

Literature provides no specific data concerning the type and the risk factors for infection in adult patients with acute lymphoblastic leukemia (ALL). We retrospectively analyzed 97 adult ALL patients who underwent conventional chemotherapy during a 14-year period with the aim to assess the incidence and the factors affecting onset and outcome of infections. We found that during induction therapy 50% of patients developed infection, mainly caused by gram-negative bacteria and with a mortality rate of 11%. In multivariate analysis age > 60 years was significantly associated with more infections (P = 0.04) and higher related mortality (P = 0.03). Moreover, in 22% of patients infectious complications occurred during consolidation or maintenance therapy. Mortality rate of these infections, mostly due to opportunistic pathogens, was 16%. Factors affecting mortality was the cumulative dose of methylprednisolone given during induction therapy ( < or = 2600 mg = 31% vs. > 2600 mg = 69%; P = 0.03). Among neutropenic patients, adults with ALL represent a peculiar population since they frequently develop gram negative infections during induction and opportunistic infections during post-remission treatments. Advanced age and high-dose meth...Continue Reading

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Citations

Sep 4, 2009·International Journal of Hematology·Fumiko TanakaShumpei Yokota
Feb 8, 2018·Annals of Hematology·Roberta Di BlasiUNKNOWN on the behalf of the SEIFEM group (Sorveglianza Epidemiologica Infezioni Fungine in Ematologia)
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Mar 19, 2015·Current Opinion in Pulmonary Medicine·Scott E Evans, David E Ost
Apr 21, 2021·Blood·Victoria da Silva-DizDaniel Herranz

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