Infectious complications in children with acute myeloid leukemia: decreased mortality in multicenter trial AML-BFM 2004

Blood Cancer Journal
K BochennekT Lehrnbecher

Abstract

Infections are an important cause for morbidity and mortality in pediatric acute myeloid leukemia (AML). We therefore characterized infectious complications in children treated according to the trial AML-BFM 2004. Patients with Down syndrome were excluded from the analysis. Data were gathered from the medical records in the hospital where the patients were treated. A total of 405 patients (203 girls; median age 8.4 years) experienced 1326 infections. Fever without identifiable source occurred in 56.1% of the patients and clinically and microbiologically documented infections in 17.5% and 32.4% of the patients, respectively. In all, 240 Gram-positive (112 viridans group streptococci) and 90 Gram-negative isolates were recovered from the bloodstream. Invasive fungal infection was diagnosed in 3% of the patients. Three children each died of Gram-negative bacteremia and invasive aspergillosis, respectively. As compared with the results of AML-BFM 93 with lower dose intensity, infection-related morbidity was slightly higher in AML-BFM 2004 (3.3. versus 2.8 infections per patient), whereas infection-related mortality significantly decreased (1.5% versus 5.4%; P=0.003). Specific anti-infective recommendations included in the treatment...Continue Reading

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Citations

Oct 30, 2016·Expert Review of Hematology·Stanislaw SchmidtThomas Lehrnbecher
Jun 9, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lars TramsenThomas Lehrnbecher
Sep 21, 2017·Journal of the Pediatric Infectious Diseases Society·Zoi Dorothea PanaTheoklis Zaoutis
Apr 19, 2018·Journal of Pediatric Oncology Nursing : Official Journal of the Association of Pediatric Oncology Nurses·Lauri A LinderAndrew Wilson
Nov 22, 2018·Current Opinion in Pediatrics·Thomas Lehrnbecher
Aug 11, 2018·Journal of Pediatric Hematology/oncology·James ReineckeKari Neemann
Jan 9, 2020·Expert Opinion on Pharmacotherapy·Nira Arad-CohenYael Shachor-Meyouhas
Mar 12, 2020·British Journal of Haematology·William R Otto, Abby M Green
Oct 22, 2016·British Journal of Haematology·Henrik Hasle, Gertjan J L Kaspers
Jan 24, 2018·Frontiers in Immunology·Pappanaicken R KumaresanDimitrios P Kontoyiannis
Feb 26, 2020·Journal of Pediatric Hematology/oncology·Veerle J RuijtersMartine van Grotel
Mar 23, 2021·Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft für Kinderheilkunde·K BochennekT Lehrnbecher
May 16, 2021·The Journal of Pediatrics·Laura Olivier-GougenheimCarine Domenech
Jun 22, 2021·Revista iberoamericana de micología·Marta González-Vicent, José Tomás Ramos-Amador
Jul 27, 2021·Frontiers in Oncology·Tao MaLian-Sheng Zhang
Aug 17, 2021·Therapeutic Advances in Infectious Disease·Kundan MishraTathagat Chaterjee

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Methods Mentioned

BETA
X-ray

Clinical Trials Mentioned

NCT00111345

Software Mentioned

GraphPad Prism
GraphPad

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