Infectious complications in chronic graft-versus-host disease: a retrospective study of 145 recipients of allogeneic hematopoietic stem cell transplantation with reduced- and conventional-intensity conditioning regimens

Transplant Infectious Disease : an Official Journal of the Transplantation Society
S YamasakiY Takaue

Abstract

To assess infectious complications associated with chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) with reduced- and conventional-intensity conditioning regimens (RIC, n=91; CIC, n=54, respectively), we retrospectively analyzed data from 145 consecutive patients with cGVHD after allogeneic HSCT from a human leukocyte antigen-matched related or unrelated donor. In the present retrospective analysis, 57% (83/145) of patients with cGVHD developed infections, with a mortality rate of 27% (22/83). The incidences of bacteremia (n=28), central venous catheter-related infections (n=11), bacterial pneumonia (n=4), invasive aspergillosis (n=7), and adenoviral hemorrhagic cystitis (n=8) were significantly higher in patients with prednisolone dose >or=1 mg/kg at the time of diagnosis of cGVHD. The present results suggest that infections associated with cGVHD, especially after high-dose prednisolone, are predictive of poor outcome regardless of whether the patient received RIC or CIC.

References

Jun 22, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C A DykewiczUNKNOWN American Society of Blood and Marrow Transplantation
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S AsciogluUNKNOWN Mycoses Study Group of the National Institute of Allergy and Infectious Diseases
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Nov 18, 2003·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A BuscaM Falda
Jan 31, 2004·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Akiko HoriYoichi Takaue
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Citations

Dec 3, 2011·Clinical Reviews in Allergy & Immunology·Syh-Jae LinMing-Ling Kuo
Aug 18, 2009·Bone Marrow Transplantation·D PulanicS Z Pavletic
Feb 7, 2009·The New England Journal of Medicine·Stuart M LevitzJohn D Cleary
Jan 18, 2011·Hematology/oncology Clinics of North America·John R WingardJohn W Hiemenz
May 15, 2010·Infectious Disease Clinics of North America·John R WingardJohn W Hiemenz
Jul 22, 2011·Stem Cells International·Marta Isabel Pereira, Artur Paiva
Dec 14, 2011·Clinical Transplantation·Manuela Aguilar-GuisadoUNKNOWN Spanish Network for Research in Infectious Diseases
Jul 17, 2012·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Stefan O CiureaRichard E Champlin
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marcie TomblynUNKNOWN Centers for Disease Control and Prevention
Jun 3, 2009·Expert Review of Anti-infective Therapy·Elio Castagnola, Maura Faraci
Nov 26, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Parthak ProdhanRichard T Fiser

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