PMID: 7524204Oct 15, 1994Paper

Infectious complications in liver transplant recipients on tacrolimus. Prospective analysis of 88 consecutive liver transplants

Transplantation
N SinghV L Yu

Abstract

This prospective study characterizes the incidence, etiology, timing, risk factors, and outcome of the infectious complications after 88 consecutive liver transplantations in 79 patients receiving tacrolimus (FK506) as primary immunosuppression with a median follow-up of 880 days. Infections occurred in 59% (47/79) of the patients, and 39% had major infections. Of the major infections, 55% were bacterial, 22% were viral, and 22% were fungal. Bacteremia accounted for 30% of major bacterial infections. Sixty percent of bacteremias occurring within the first 3 months were catheter related, while 75% of those occurring more than 3 months after transplant were of a biliary source. Patients with recurrent hepatitis C virus hepatitis and patients requiring dialysis after transplant had a significantly higher rate of infections as compared with other patients. Overall mortality was 18%, and 29% of all deaths were associated with infection. Only invasive aspergillosis was associated with infectious mortality. Our data suggest that the potent immunosuppressive agent FK506 is not associated with a higher incidence of infectious complications as compared with previous studies using CsA.

Citations

Jan 1, 1996·Transplant International : Official Journal of the European Society for Organ Transplantation·L M BarkholtA Lindé
Feb 3, 1998·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·N SinghI R Marino
Jul 6, 2006·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·S KohlerP Neuhaus
Mar 12, 1999·The Surgical Clinics of North America·G V MazariegosD J Kramer
Sep 10, 2003·Transplantation Proceedings·J R PerairaL Alonso-Pulpón
Feb 24, 2001·Alimentary Pharmacology & Therapeutics·E IerardiA Francavilla
Apr 12, 2012·Journal of Clinical Microbiology·Peter-Michael RathJoerg Steinmann
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·N SinghI R Marino
Feb 15, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·N SinghM M Wagener
May 30, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Y J KimM W Kang
Apr 26, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Claire BellierBruno Fantin
Jul 4, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·C M DenkingerL M Dowdy
Jul 4, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M HashimotoM Makuuchi
Sep 25, 2008·Transplant Infectious Disease : an Official Journal of the Transplantation Society·M HashimotoM Makuuchi
Apr 3, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jayant S KalpoeShirish Huprikar
Apr 5, 2003·Intensive Care Medicine·Chaker Ben HamidaFrançois Stéphan
Apr 18, 2003·Critical Care Clinics·Anatoli KraskoSteven Bonvino
Mar 1, 1997·The Journal of Surgical Research·T GayowskiN Singh
Sep 1, 2015·PloS One·Masaki YamamotoSatoshi Ichiyama
Jul 3, 2015·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marcus R PereiraElizabeth C Verna
May 26, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nina SinghThomas V Cacciarelli
Jul 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nina SinghTimothy Gayowski
Jun 29, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michiel C WarléGerda J Bouma
Mar 23, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Connie L DavisAlan H Wilkinson
Feb 9, 2006·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Nina SinghThomas V Cacciarelli
Feb 9, 2017·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Cybele Lara R AbadRaymund R Razonable
Oct 27, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·N SinghT Gayowski
Sep 17, 2004·Transplantation·Yoshitsugu IinumaSatoshi Ichiyama
Jun 27, 2008·Transplantation·María E García PradoJosé M Cisneros Herreros
Jan 27, 1998·Journal of Pediatric Gastroenterology and Nutrition·S V McDiarmid
Jan 5, 2000·Clinical Transplantation·N SinghI R Marino

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