Infectious Complications of Biological and Small Molecule Targeted Immunomodulatory Therapies.

Clinical Microbiology Reviews
Joshua S DavisMichael Boyle

Abstract

The past 2 decades have seen a revolution in our approach to therapeutic immunosuppression. We have moved from relying on broadly active traditional medications, such as prednisolone or methotrexate, toward more specific agents that often target a single receptor, cytokine, or cell type, using monoclonal antibodies, fusion proteins, or targeted small molecules. This change has transformed the treatment of many conditions, including rheumatoid arthritis, cancers, asthma, and inflammatory bowel disease, but along with the benefits have come risks. Contrary to the hope that these more specific agents would have minimal and predictable infectious sequelae, infectious complications have emerged as a major stumbling block for many of these agents. Furthermore, the growing number and complexity of available biologic agents makes it difficult for clinicians to maintain current knowledge, and most review articles focus on a particular target disease or class of agent. In this article, we review the current state of knowledge about infectious complications of biologic and small molecule immunomodulatory agents, aiming to create a single resource relevant to a broad range of clinicians and researchers. For each of 19 classes of agent, we ...Continue Reading

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M B MazanecJ G Nedrud
Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Jan 1, 1991·International Journal of Immunopharmacology·D DelfinoC Riccardi
Nov 1, 1991·The Journal of Clinical Investigation·W P Arend
Oct 1, 1989·The Journal of Allergy and Clinical Immunology·M M Frank
Oct 1, 1987·Sexually Transmitted Diseases·R T EllisonF N Judson
Sep 1, 1987·The Pediatric Infectious Disease Journal·D Beatty
May 1, 1980·The Journal of Investigative Dermatology·L B Schwartz, K F Austen
May 1, 1995·Stem Cells·K BendtzenM Svenson
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·P J MauserR W Chapman
Sep 1, 1995·American Journal of Respiratory Cell and Molecular Biology·T T KungR W Chapman
Jan 1, 1995·Cancer Treatment and Research·M Lotz
Jun 6, 1997·The Journal of Biological Chemistry·M KanzakiI Kojima
Jun 1, 1997·American Journal of Respiratory and Critical Care Medicine·J V FahyH A Boushey
Jun 1, 1997·American Journal of Respiratory and Critical Care Medicine·L P BouletD W Cockcroft
Oct 29, 1998·Mediators of Inflammation·V H van der Velden
Dec 31, 1998·Arthritis and Rheumatism·B BresnihanP Musikic
Jul 15, 1999·The New England Journal of Medicine·S FaderlH M Kantarjian
Jul 17, 1999·International Journal of Immunopharmacology·N MagyF Stoll-Keller
Feb 29, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M JacobsB Ryffel
Sep 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·H OchiJ A Boyce
Feb 13, 2001·European Journal of Immunology·L A van PinxterenP Andersen
Mar 13, 2001·Annual Review of Immunology·M Feldmann, R N Maini
Mar 15, 2001·European Journal of Gastroenterology & Hepatology·S Campbell, S Ghosh
Apr 5, 2001·The New England Journal of Medicine·B J DrukerC L Sawyers
Apr 20, 2001·Heart Failure Reviews·K C Wollert, H Drexler

❮ Previous
Next ❯

Citations

Mar 16, 2021·Anesthesiology·Grace HoganGerard F Curley
Jul 8, 2021·Expert Opinion on Pharmacotherapy·Adam G Stewart, David L Paterson
Aug 8, 2021·Diagnostics·Carlo Foppiano Palacios, Anne Spichler Moffarah
Jul 15, 2021·Current Opinion in Rheumatology·Mario Abinun, Mary A Slatter
Aug 19, 2021·Cell Death & Disease·Céline BarlierAntonio Del Sol
Oct 5, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Christos KyriakopoulosKonstantinos Kostikas
Oct 22, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Bob Geng, Timothy J Craig
Oct 23, 2021·Medical Mycology·Stefan KlugeTobias Lahmer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Trends in Molecular Medicine
Susan W Liebman, James A Mastrianni
Journal of Public Health Management and Practice : JPHMP
Lloyd F Novick
Current Opinion in Investigational Drugs
Jimmy Hwang, John L Marshall
© 2022 Meta ULC. All rights reserved