Infectious disease in the blood supply and the public health response

Seminars in Hematology
Bruce Evatt

Abstract

The consistent improvements in hemophilia care seen in the years 1960 to 1980 halted when human immunodeficiency virus (HIV) appeared in the blood supply. In the early 1980s, before HIV virulence was fully understood, a complacent blood therapy industry and its regulators waffled on an appropriate response. As a result, the period between the appearance of HIV and its effective elimination from the blood supply was lengthy and many recipients of blood therapies became infected, with devastating impact on their quality of life, quality of care, and longevity. As the decade wore on, even as they began to better understand the threat, industry and public health officials continued to stall, in part because development of interventions was costly and cumbersome. In order to protect the safety of the blood supply and blood-derived therapies, it must be recognized that new pathogens will continue to emerge. Agencies' and companies' decision-making processes in this regard must therefore be proactive rather than reactive, and should preferably implement a formalized risk-management approach. The ongoing safety of blood therapies and the blood supply will also depend on continued vigilance and research. Finally, the hemophilia communit...Continue Reading

References

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Citations

Oct 31, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·R B ButlerA D Forsberg
Aug 5, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·J EpsteinJ Li-McLeod
Jun 22, 2015·Biologicals : Journal of the International Association of Biological Standardization·Justin McCueHeidi Reichert
Sep 24, 2014·American Journal of Preventive Medicine·Christopher S ParkerLisa C Richardson
Feb 13, 2016·Journal of Medical Ethics·Marcel Verweij, Koen Kramer
Feb 20, 2018·BMC Health Services Research·Jan A GrawRene Burchard
Jul 5, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Javier BatlleCarlos Aguilar
Jul 19, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Kanjaksha Ghosh, Kinjalka Ghosh

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