Infectious disease ward admission positively influences P. jiroveci pneumonia (PjP) outcome: A retrospective analysis of 116 HIV-positive and HIV-negative immunocompromised patients

PloS One
Alessandra RicciardiLoredana Sarmati

Abstract

P. jiroveci (Pj) causes a potentially fatal pneumonia in immunocompromised patients and the factors associated with a bad outcome are poorly understood. A retrospective analysis on Pj pneumonia (PjP) cases occurring in Tor Vergata University Hospital, Italy, during the period 2011-2015. The patients' demographic, clinical and radiological characteristics and the Pj genotypes were considered. The study population included 116 patients, 37.9% of whom had haematological malignancy or underwent haematological stem cell transplantation (HSCT), 22.4% had HIV infection, 16.4% had chronic lung diseases (CLD), 7.8% had a solid cancer, and 3.4% underwent a solid organ transplant (SOT). The remaining 12.1% had a miscellaneous other condition. At univariate analysis, being older than 60 years was significantly correlated with a severe PjP (OR [95%CI] 2.52 [0.10-5.76]; p = 0.031) and death (OR [95%CI] 2.44 [1.05-5.70]; p = 0.036), while a previous trimethoprim/sulfamethoxazole (TMP/SMX) prophylaxis were significantly associated with a less severe pneumonia (OR[95%CI] 0.35 [0.15-0.84], p = 0.023); moreover, death due to PjP was significantly more frequent in patients with CLD (OR[95%CI] 3.26 [1.17-9.05]; p = 0.019) while, admission to the In...Continue Reading

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Citations

Oct 23, 2019·Frontiers in Public Health·Estefanía Pereira-DíazFrancisco J Medrano
Jun 23, 2020·Case Reports in Gastrointestinal Medicine·Hafsa AbbasSridhar Chilimuri
Nov 21, 2018·Critical Care : the Official Journal of the Critical Care Forum·Julius J SchmidtSascha David
Jul 6, 2021·Frontiers in Public Health·Yuqiong WangQingyuan Zhan

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Methods Mentioned

BETA
PCR
genotyping
bronchoalveolar
lavage
PCRs
electrophoresis

Software Mentioned

FinchTV
SPSS

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