Infectious diseases of marine molluscs and host responses as revealed by genomic tools

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
Ximing Guo, Susan E Ford

Abstract

More and more infectious diseases affect marine molluscs. Some diseases have impacted commercial species including MSX and Dermo of the eastern oyster, QPX of hard clams, withering syndrome of abalone and ostreid herpesvirus 1 (OsHV-1) infections of many molluscs. Although the exact transmission mechanisms are not well understood, human activities and associated environmental changes often correlate with increased disease prevalence. For instance, hatcheries and large-scale aquaculture create high host densities, which, along with increasing ocean temperature, might have contributed to OsHV-1 epizootics in scallops and oysters. A key to understanding linkages between the environment and disease is to understand how the environment affects the host immune system. Although we might be tempted to downplay the role of immunity in invertebrates, recent advances in genomics have provided insights into host and parasite genomes and revealed surprisingly sophisticated innate immune systems in molluscs. All major innate immune pathways are found in molluscs with many immune receptors, regulators and effectors expanded. The expanded gene families provide great diversity and complexity in innate immune response, which may be key to mollus...Continue Reading

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Feb 18, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kevin D Lafferty, Eileen E Hofmann
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Dec 2, 2021·The Science of the Total Environment·Marco BasiliGrazia Marina Quero

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