Infective endocarditis caused by community-associated methicillin-resistant Staphylococcus aureus in a previously healthy preschool child

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
Chun-Yi LeeYhu-Chering Huang

Abstract

Community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) has been increasingly reported recently and has become an emerging pathogen of infective endocarditis (IE) in adults, but still rarely reported in children. A previously healthy preschool child without any heart anomaly developed IE and pneumonia with pleural effusion. Blood cultures repeatedly yielded MRSA and did not become negative until 13 days after a teicoplanin-containing regimen was administered. In total, a 4-week intravenous antibiotic therapy and an additional 8-week oral antibiotic therapy were given. The patient recovered uneventfully. All five MRSA blood isolates were molecularly characterized and shared common characteristics, which were consistent with those of the endemic CA-MRSA clone in Taiwan. This case highlights that physicians should be aware of the growing role of CA-MRSA in childhood IE and should meticulously choose an appropriate empiric antibiotic regimen for such a severe disease.

References

Dec 11, 2003·JAMA : the Journal of the American Medical Association·Timothy S NaimiRuth Lynfield
Jun 15, 2005·Journal of Paediatrics and Child Health·Stuart Lewena
Feb 21, 2008·The Journal of Antimicrobial Chemotherapy·Hung-Chin TsaiYung-Ching Liu
Feb 4, 2009·Circulation·Michael D DayJane W Newburger
May 1, 2010·The Pediatric Infectious Disease Journal·Maria A Carrillo-MarquezSheldon L Kaplan
Jan 11, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine LiuHenry F Chambers

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Citations

Jun 21, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·C SousaR Oliveira
Feb 5, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Kao-Hsian HsiehChih-Chien Wang
Sep 7, 2014·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Beiwen ZhengLanjuan Li
Feb 26, 2016·Heart·B Cherie MillarJohn E Moore
Jun 28, 2019·International Journal of Environmental Research and Public Health·Cheng-Jei LinTzu-Hsien Tsai

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