Since the 1960s chronic hemodialysis (HD) has been recognized as a risk factor for the development of infective endocarditis (IE). Historically, it has been particularly associated with vascular access via dual lumen catheters. We wished to examine the risk factors for, and consequences of, IE in the modern dialysis era. Cases of IE (using the Duke criteria) at St. Thomas' Hospital (1980 to 1995), Guy's (1995 to 2002), and King's College Hospitals (1996 to 2002) were reviewed. Twenty-eight patients were identified as having developed IE (30 episodes of IE). Twenty-seven patients were on long-term HD and one patient was on peritoneal dialysis (PD). Mean age was 54.1 years, and mean duration of HD prior to IE was 46.3 months. Eight patients were diabetic. Primary HD hemoaccess was an arteriovenous fistula (AVF) in 41.3%, a dual-lumen tunneled catheter (DLTC) in 37.9%, a polytetrafluoroethylene (PTFE) graft in 10.3%, and a dual- lumen non-tunneled catheter (DLNTC) in 4%. The presumed source of sepsis was directly related to hemoaccess in 25 HD patients: DLTC in 48%; AVF in 32%; PTFE in 12%; and DLNTC in 4%. Staphylococcus aureus[including methicillin resistant Staphylococcus aureus (MRSA)] was present in 63.3%. The mitral valve wa...Continue Reading
Slow response to vancomycin or vancomycin plus rifampin in methicillin-resistant Staphylococcus aureus endocarditis
Antibiotic treatment of adults with infective endocarditis due to streptococci, enterococci, staphylococci, and HACEK microorganisms. American Heart Association
New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke Endocarditis Service
Catheter-related bacteremia and outcome of attempted catheter salvage in patients undergoing hemodialysis
EPIBACDIAL: a multicenter prospective study of risk factors for bacteremia in chronic hemodialysis patients.
Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease?
An in vitro evaluation of the antibiotic/heparin lock to sterilize central venous haemodialysis catheters
Infective endocarditis caused by Salmonella enteritidis in a dialysis patient: a case report and literature review
Cardiovascular morbidity and mortality in patients treated with hemodialysis--epidemiological analysis
Infective endocarditis in hemodialysis patients: clinical features, echocardiographic data and outcome: a 10-year descriptive analysis
High Risk of Prosthetic Valve Endocarditis and Death After Valve Replacement Operations in Dialysis Patients
Definite infective endocarditis: clinical and microbiological features of 155 episodes in one Japanese university hospital
Current features of infective endocarditis in persons on hemodialysis: a prevalence study with case control design from the prospective multicenter SEI cohort
Massive calcified tricuspid valve endocarditis in a patient with dual lumen tunneled venous catheter
Aspirin treatment is associated with a significantly decreased risk of Staphylococcus aureus bacteremia in hemodialysis patients with tunneled catheters
Physiopathological approach to infective endocarditis in chronic hemodialysis patients: left heart versus right heart involvement
Long-term survival of dialysis patients with bacterial endocarditis undergoing valvular replacement surgery in the United States
Cardiac valve replacement for infective endocarditis in patients with end stage renal disease on hemodialysis - A single institution experience
A case of histopathologically confirmed infective endocarditis with no vegetations observed during preoperative diagnosis
The impact of hemodialysis on mortality risk and cause of death in Staphylococcus aureus endocarditis
Inherited Variation in Cytokine, Acute Phase Response, and Calcium Metabolism Genes Affects Susceptibility to Infective Endocarditis
Infective Endocarditis and Its Short and Long-Term Prognosis in Hemodialysis Patients: A Systematic Review and Meta-analysis.
CRISPR & Staphylococcus
CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.