PMID: 11931207Apr 5, 2002Paper

Infective endocarditis: report of a prospective study in an Indian hospital

Tropical Doctor
B KhanalS Srinivasan

Abstract

Forty-six patients who fulfilled the Duke's clinical diagnostic criteria for infective endocarditis (IE) were evaluated. Thirty-five (76%) patients were below 40 years of age with rheumatic heart disease being the most common underlying heart lesion affecting 26 (56%). An obvious predisposing cardiac lesion could not be ascertained in 22%. Blood culture positivity was 44% with streptococcus heading the list. The incidence of the staphylococcal (25%) and gram negative bacillary endocarditis (15%) were found to be increasing. Streptococci were susceptible to penicillin with minimum bactericidal concentration: minimum inhibitory concentration within acceptable limits. However, the appearance of methicillin resistant staphylococcus aureus and high level gentamicin resistant enterococcus as aetiological agents of infective endocarditis were found to add to the complexity of the problem. With the emergence of drug-resistant organisms as causative agents of IE, whenever medical therapy is the primary method of treatment of this condition, the selection of antibiotics should depend upon extensive in vitro testing and in vivo monitoring of clinical efficacy.

References

Dec 1, 1992·The American Journal of Cardiology·R ChoudhuryR P Sapru
Nov 1, 1992·Journal of Clinical Pathology·A C McCartney
Mar 1, 1987·British Heart Journal·I R Gray
Jan 1, 1986·American Journal of Obstetrics and Gynecology·B J Seaworth, D T Durack
Dec 1, 1983·British Heart Journal·R BaylissA G Whitfield
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Feb 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R M Sandre, S D Shafran

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Citations

Apr 3, 2018·Cardiology in Review·E Anne RussellGraeme P Maguire
Dec 25, 2008·Circulation·Jonathan R Carapetis
Dec 19, 2013·PloS One·Leandro SlipczukVincent M Figueredo
Aug 3, 2021·The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien Des Maladies Infectieuses Et De La Microbiologie Médicale·Sohani BajracharyaSanjib Kumar Sharma

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