Infective exacerbations of chronic bronchitis: relation between bacteriologic etiology and lung function

Chest
J EllerH Lode

Abstract

In patients with severe COPD, acute infective exacerbations are frequent. Streptococcus pneumoniae and Haemophilus influenzae are the most commonly isolated bacteria in sputum cultures from these patients. We hypothesized that in patients with advanced disease, Gram-negative bacteria other than H influenzae play at least an equally important role. We evaluated clinical data and sputum culture results from 211 unselected COPD patients admitted to our hospital with an acute infective exacerbation of COPD. One hundred twelve patients fulfilled our protocol criteria of reliable microbiologic results and reproducible lung function tests; the patients were categorized according to the recently published three stages of severity. Lung function tests revealed an FEV1 of > or =50% of the predicted value in 30 patients (stage I), an FEV1 of 35% to <50% of the predicted value in 30 patients (stage II), and an FEV1 of < or =35% of the predicted value in 34 patients (stage III). Bacteria were classified into three groups: group 1 contained S pneumoniae and other Gram-positive cocci; group 2, H influenzae and Moraxella catarrhalis; and group 3, Enterobacteriaceae and Pseudomonas spp. For all patients together, the most frequently isolated ba...Continue Reading

References

Mar 13, 1975·The New England Journal of Medicine·I Tager, F E Speizer
Jun 25, 1977·British Medical Journal·C Fletcher, R Peto
Oct 1, 1992·The American Review of Respiratory Disease·T F Murphy, S Sethi
Feb 20, 1969·The New England Journal of Medicine·B Burrows, R H Earle
Mar 22, 1995·JAMA : the Journal of the American Medical Association·S SaintD Grady
Sep 1, 1993·The American Review of Respiratory Disease·A Buret, A W Cripps

❮ Previous
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Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·David Lieberman, Devora Lieberman
May 31, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Tsuyoshi UmeharaKwang Chul Kim
Jan 27, 2007·Current Infectious Disease Reports·Paolo TarsiaFrancesco Blasi
Mar 23, 2012·Current Infectious Disease Reports·Salvador SialerAntoni Torres
May 28, 2004·Comprehensive Therapy·Fernando J Martinez
Dec 14, 2010·Archivos de bronconeumología·Miguel Angel Martínez García, Juan José Soler Cataluña
Aug 15, 2001·Diagnostic Microbiology and Infectious Disease·D LiebermanI Boldur
Sep 28, 2001·International Journal of Antimicrobial Agents·H E Akalin
May 15, 2002·International Journal of Antimicrobial Agents·Alistair Leanord, Craig Williams
Jun 7, 2003·International Journal of Antimicrobial Agents·Jan Verhoef, A Gillissen
Apr 30, 1999·International Journal of Antimicrobial Agents·J S BradleyJ P Quinn
May 13, 2003·Clinical Cornerstone·Amy R Blanchard
Jul 1, 2004·Archivos de bronconeumología·M Miravitlles, UNKNOWN Grupo de trabajo de la Asociación Latinoamericana del Tórax (ALAT)
Sep 5, 2006·Archivos de bronconeumología·Carles LlorAmadeo Herreras
Jul 18, 2002·Journal of the American Geriatrics Society·Robert A Bonomo
Aug 16, 2002·The New England Journal of Medicine·Sanjay SethiTimothy F Murphy
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul van der ValkRon Hendrix
Nov 26, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy F Murphy
Mar 31, 2000·Current Opinion in Pulmonary Medicine·A Fein, A M Fein
Jun 18, 2009·Current Opinion in Pulmonary Medicine·Timothy F Murphy
Jun 18, 2009·Current Opinion in Pulmonary Medicine·Daiana Stolz, Michael Tamm
Feb 15, 2007·Respirology : Official Journal of the Asian Pacific Society of Respirology·Omer S Alamoudi
Aug 14, 2008·Respirology : Official Journal of the Asian Pacific Society of Respirology·Miquel FalgueraJosé M Porcel
Jan 10, 2002·Clinical Microbiology Reviews·Cees M VerduinAlex van Belkum
Aug 19, 2004·Annales Universitatis Mariae Curie-Skłodowska. Sectio D: Medicina·Robert KieszkoJanusz Milanowski
Sep 15, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Umadevi SajjanMarc B Hershenson
Oct 26, 2012·Interdisciplinary Perspectives on Infectious Diseases·Axel Dalhoff
Aug 20, 2004·American Journal of Respiratory and Critical Care Medicine·Anna G DrannikMartin R Stämpfli
Jan 19, 2008·American Journal of Respiratory and Critical Care Medicine·Timothy F MurphySanjay Sethi
Jun 27, 2009·American Journal of Respiratory and Critical Care Medicine·Mark T DransfieldUNKNOWN COPD Clinical Research Network
Nov 23, 2001·Pharmacotherapy·J D Adkison, S L Konzem
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Francesco BlasiLuigi Allegra
Sep 13, 2012·International Journal of Chronic Obstructive Pulmonary Disease·Victoria BeasleyPatrick Mallia
Jul 23, 2013·International Journal of Chronic Obstructive Pulmonary Disease·Ho Ii YoonChul-Gyu Yoo
May 14, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Carl LlorUNKNOWN BRAMOX Study Group
Jun 26, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Sean H Ling, Stephan F van Eeden

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