PMID: 8999Sep 1, 1976

Infective larvae of Brugia: escape from mosquitoes into water and subsequent oral infectivity in jirds

The American Journal of Tropical Medicine and Hygiene
W BosworthE Chernin

Abstract

Published work showed that third-stage larvae (L-3s) escape into water from dead or dying, Brugia pahangi-infected, Aedes aegypti. The present study revealed the same escape phenomenon among B. pahangi-infected Armigeres subalbatus, Anopheles quadrimaculatus, and Aedes togoi, and among Brugia malayi-infected Ae. aegypti and Ae. togoi. L-3s maintained in water or in Lum's solution for 3 hours retained infectivity when tested in orally or subcutaneously exposed jirds; furthermore, L-3s recovered from mosquitoes dead for 24 to 48 hours were also infective by either portal of entry in jirds. Since L-3s may escape and remain infective in the field, it is conceivable that natural filarial infections might thus be acquired orally by definitive hosts.

Related Concepts

Aedes
Brugia
Filariasis
Litomosoides
Psammomys
Tadpole
Culicidae