Infectivity and Transmissibility of Avian H9N2 Influenza Viruses in Pigs

Journal of Virology
Jia WangYi Guan

Abstract

The H9N2 influenza viruses that are enzootic in terrestrial poultry in China pose a persistent pandemic threat to humans. To investigate whether the continuous circulation and adaptation of these viruses in terrestrial poultry increased their infectivity to pigs, we conducted a serological survey in pig herds with H9N2 viruses selected from the aquatic avian gene pool (Y439 lineage) and the enzootic terrestrial poultry viruses (G1 and Y280 lineages). We also compared the infectivity and transmissibility of these viruses in pigs. It was found that more than 15% of the pigs sampled from 2010 to 2012 in southern China were seropositive to either G1 or Y280 lineage viruses, but none of the sera were positive to the H9 viruses from the Y439 lineage. Viruses of the G1 and Y280 lineages were able to infect experimental pigs, with detectable nasal shedding of the viruses and seroconversion, whereas viruses of the Y439 lineage did not cause a productive infection in pigs. Thus, adaptation and prevalence in terrestrial poultry could lead to interspecies transmission of H9N2 viruses from birds to pigs. Although H9N2 viruses do not appear to be continuously transmissible among pigs, repeated introductions of H9 viruses to pigs naturally in...Continue Reading

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Citations

Dec 11, 2019·Microorganisms·Kirill SharshovTakehiko Saito
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Silvia Carnaccini, Daniel R Perez
Jul 12, 2020·Transboundary and Emerging Diseases·Fabian O Chamba PardoMontserrat Torremorell
Jul 29, 2020·Avian Pathology : Journal of the W.V.P.A·Leslie D SimsDavid E Swayne
Apr 7, 2017·PloS One·Jose Carlos Mancera GraciaKristien Van Reeth
Sep 27, 2018·Veterinary Sciences·Elizabeth A Pusch, David L Suarez
Oct 16, 2017·EFSA Journal·UNKNOWN European Food Safety AuthorityFrank Verdonck
Jul 10, 2019·Viruses·T Homas P PeacockMunir Iqbal
Nov 1, 2017·Transboundary and Emerging Diseases·K Wei, Y Li

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