Infectivity of Chronic Malaria Infections and Its Consequences for Control and Elimination

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Ricardo AguasArjen M Dondorp

Abstract

Assessing the importance of targeting the chronic Plasmodium falciparum malaria reservoir is pivotal as the world moves toward malaria eradication. Through the lens of a mathematical model, we show how, for a given malaria prevalence, the relative infectivity of chronic individuals determines what intervention tools are predicted be the most effective. Crucially, in a large part of the parameter space where elimination is theoretically possible, it can be achieved solely through improved case management. However, there are a significant number of settings where malaria elimination requires not only good vector control but also a mass drug administration campaign. Quantifying the relative infectiousness of chronic malaria across a range of epidemiological settings would provide essential information for the design of effective malaria elimination strategies. Given the difficulties obtaining this information, we also provide a set of epidemiological metrics that can be used to guide policy in the absence of such data.

References

May 1, 1993·The American Journal of Tropical Medicine and Hygiene·C BoudinP Ambroise-Thomas
Mar 31, 2004·Medical Hypotheses·Mathieu Nacher
Apr 6, 2004·Journal of Medical Entomology·Russell E ColemanJetsumon Sattabongkot
Oct 21, 2004·The Cochrane Database of Systematic Reviews·N AdhikariM O Meade
Mar 13, 2008·PloS One·Ricardo AguasM Gabriela M Gomes
Oct 14, 2010·Malaria Journal·André Lin OuédraogoRobert Sauerwein
Oct 3, 2012·PloS One·Ingrid FelgerThomas A Smith
Jun 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David L SmithAndrew J Tatem
Mar 20, 2014·Trends in Parasitology·Jessica T LinSteven R Meshnick
Jan 20, 2015·Nature Communications·Thomas S ChurcherAnna Cohuet
Jan 28, 2015·The American Journal of Tropical Medicine and Hygiene·Abdoulaye GayeCheikh Sokhna
Aug 5, 2015·Malaria Journal·Michael T BretscherTom Smith
Aug 15, 2015·Nature Reviews. Microbiology·Gabrielle A Josling, Manuel Llinás
Mar 2, 2016·Scientific Data·N Claire MasseyMarianne E Sinka

❮ Previous
Next ❯

Citations

Nov 14, 2019·Expert Review of Anti-infective Therapy·James CheaveauDylan R Pillai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

© 2022 Meta ULC. All rights reserved