PMID: 16520543Mar 8, 2006Paper

Infectivity of porcine circovirus 1 and circovirus 2 in primary porcine hepatocyte and kidney cell cultures

The Journal of Veterinary Medical Science
Takuya HiraiKeigo Nakamura

Abstract

Infectivity of porcine circovirus (PCV) 1 and PCV2 was examined in primary porcine hepatocyte culture by comparing that of PCV in primary kidney cell culture. The virus titer of PCV2-infected hepatocyte cultures was higher than that of the PCV1-infected hepatocyte cultures and the PCV-infected kidney cell cultures. The number of virus-positive cells was most abundant in PCV2-infected hepatocyte cultures as determined by immunohistochemistry and/or in situ hybridization. The results of our data suggest that PCV2 preferably infects cultured hepatocytes as observed in the liver of pigs with postweaning multisystemic wasting syndrome.

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Citations

Mar 23, 2011·Research in Veterinary Science·L V SøndergaardM S Herskin
Jul 12, 2008·Virology·Esther SteinerKenneth McCullough

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