Inference of complex population histories using whole-genome sequences from multiple populations

Proceedings of the National Academy of Sciences of the United States of America
Matthias SteinrückenYun S Song

Abstract

There has been much interest in analyzing genome-scale DNA sequence data to infer population histories, but inference methods developed hitherto are limited in model complexity and computational scalability. Here we present an efficient, flexible statistical method, diCal2, that can use whole-genome sequence data from multiple populations to infer complex demographic models involving population size changes, population splits, admixture, and migration. Applying our method to data from Australian, East Asian, European, and Papuan populations, we find that the population ancestral to Australians and Papuans started separating from East Asians and Europeans about 100,000 y ago, and that the separation of East Asians and Europeans started about 50,000 y ago, with pervasive gene flow between all pairs of populations.

References

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Citations

Oct 3, 2020·Evolutionary Applications·Nina Marchi, Laurent Excoffier
Jan 16, 2021·Molecular Ecology Resources·Christelle FraïsseCamille Roux
Dec 8, 2019·Trends in Ecology & Evolution·Maeva LeitweinLouis Bernatchez
May 13, 2021·Molecular Ecology Resources·Thibaut Paul Patrick SellingerAurélien Tellier
Jun 25, 2021·Bioinformatics·Laurent ExcofffierVitor C Sousa

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