Inference of population structure using multilocus genotype data: dominant markers and null alleles

Molecular Ecology Notes
Daniel FalushJonathan K Pritchard

Abstract

Dominant markers such as amplified fragment length polymorphisms (AFLPs) provide an economical way of surveying variation at many loci. However, the uncertainty about the underlying genotypes presents a problem for statistical analysis. Similarly, the presence of null alleles and the limitations of genotype calling in polyploids mean that many conventional analysis methods are invalid for many organisms. Here we present a simple approach for accounting for genotypic ambiguity in studies of population structure and apply it to AFLP data from whitefish. The approach is implemented in the program structure version 2.2, which is available from http://pritch.bsd.uchicago.edu/structure.html.

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Citations

Aug 10, 2004·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·I J MaureiraT C Osborn
Jul 21, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Sheh May TamMarie-Angèle Grandbastien
Sep 18, 2009·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Ming L WangJianming Yu
Apr 7, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Liang JinJinsong Bao
Mar 14, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Monica RodriguezGiovanna Attene
Mar 29, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Muhammad Javed IqbalHarbans L Bhardwaj
Nov 6, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Matthew W BlairDoug R Cook
Sep 28, 2013·European Archives of Psychiatry and Clinical Neuroscience·Sibylle G Schwab, Dieter B Wildenauer
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Feb 12, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carolien I PanhuysenJoel Gelernter
Mar 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Adriana LoriJoseph F Cubells
Oct 6, 2010·The Pharmacogenomics Journal·T M Baye, R A Wilke
Apr 24, 2010·Médecine sciences : M/S·Simone Gilgenkrantz
Jan 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gabriele GentileValerio Sbordoni

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Methods Mentioned

BETA
PCR
genotyping

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