PMID: 3747711Sep 8, 1986Paper

Inferior colliculus neuronal response abnormalities in genetically epilepsy-prone rats: evidence for a deficit of inhibition

Life Sciences
C L FaingoldD M Caspary

Abstract

The genetically epilepsy-prone rat (GEPR) is abnormally susceptible to induction of seizures by acoustic stimulation. The inferior colliculus (IC) is critically important to audiogenic seizure susceptibility. The GEPR is more susceptible to induction of audiogenic seizures at 12 kHz than at other pure tone frequencies. IC neurons in the GEPR exhibit significantly elevated response thresholds and broader tuning characteristics than normal. These findings along with previous neurophysiological and anatomical data suggest that a hearing deficit occurs in the GEPR. IC neurons in the GEPR exhibit a significantly elevated incidence of a response pattern with a peak of activity at the beginning and end of the stimulus, the onset-offset response. This response pattern occurs at 12 kHz and at characteristic frequency with high stimulus intensities and may represent an afterdischarge phenomenon. The onset-offset pattern may be a manifestation of central mechanisms developed to compensate for reduced peripheral auditory input that appears to be involved in the hearing deficit of the GEPR. Such compensatory mechanisms may involve alterations of the actions of neurotransmitters of the brain-stem auditory nuclei. GABA is implicated as an inh...Continue Reading

References

Sep 3, 1976·Brain Research·D H VersteegM Palkovits
Mar 1, 1986·Electroencephalography and Clinical Neurophysiology·C L FaingoldD M Caspary
Jan 1, 1985·Annual Review of Neuroscience·J F Tallman, D W Gallager
Aug 1, 1973·Journal of Comparative and Physiological Psychology·K R Henry, M Saleh
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Aug 1, 1970·Experimental Neurology·J A WadaE Jung
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Jan 1, 1983·Hearing Research·H Davis
Nov 1, 1976·Journal of Neurochemistry·S K Fisher, W E Davies

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Citations

Jun 1, 1987·Metabolic Brain Disease·C L Faingold
Aug 1, 1989·Molecular and Chemical Neuropathology·H E Laird
Dec 20, 1993·Behavioural Brain Research·N Garcia-CairascoM C Doretto
Jan 1, 1988·General Pharmacology·C L Faingold
Jan 1, 1994·Brain Research Bulletin·P C JobeJ W Dailey
Oct 1, 1992·Epilepsy Research·M Pierson, S L Liebmann
Apr 14, 2016·Epilepsy & Behavior : E&B·Luis J MuñozDolores E López
Feb 9, 2006·Neurobiology of Aging·Jiri PopelarJosef Syka
Feb 28, 2009·Neurobiology of Aging·U-Cheng LeongJoseph P Walton
Feb 27, 2001·Hearing Research·F A BoettcherJ R Dubno
Apr 29, 2004·Clinical EEG and Neuroscience·Phillip C Jobe
Feb 17, 2009·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N Garcia-Cairasco
May 17, 2017·Epilepsy & Behavior : E&B·Norberto Garcia-CairascoJosé A Cortes de Oliveira
Mar 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A NehligC Marescaux

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