Inferior olivary lesions after local injections of 3-acetylpyridine in rabbits

Neuroscience Research
C D Balaban

Abstract

This report presents evidence that local injections of 3-acetylpyridine (3-AP) produce circumscribed lesions of the inferior olive (IO) in rabbits. These restricted lesions, assessed in both cresyl violet-stained sections after a 14-day survival and cupric-silver-stained sections after a 16-24 h survival period, are similar in appearance to lesions produced by systemic 3-AP administration in rats. Two types of degeneration are observed: destruction of cells at the injection site and more diffuse cell death in the ipsilateral and contralateral inferior olive. The latter type of degeneration appears to result from IO fiber-of-passage uptake of 3-AP. There was no evidence of lesions in surrounding structures or in sources of axons passing through periolivary regions. Thus, this protocol is a promising tool for studies of climbing fiber connectivity and physiology in rabbits.

References

Dec 19, 1975·Science·R LlinásC Sotelo
Sep 1, 1968·Zeitschrift Für Klinische Chemie Und Klinische Biochemie·H Herken
Aug 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·R E COGGESHALL, P D MACLEAN

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