Inferotemporal cortex multiplexes behaviorally-relevant target match signals and visual representations in a manner that minimizes their interference

PloS One
Noam Roth, Nicole C Rust

Abstract

Finding a sought visual target object requires combining visual information about a scene with a remembered representation of the target to create a "target match" signal that indicates when a target is in view. Target match signals have been reported to exist within high-level visual brain areas including inferotemporal cortex (IT), where they are mixed with representations of image and object identity. However, these signals are not well understood, particularly in the context of the real-world challenge that the objects we search for typically appear at different positions, sizes, and within different background contexts. To investigate these signals, we recorded neural responses in IT as two rhesus monkeys performed a delayed-match-to-sample object search task in which target objects could appear at a variety of identity-preserving transformations. Consistent with the existence of behaviorally-relevant target match signals in IT, we found that IT contained a linearly separable target match representation that reflected behavioral confusions on trials in which the monkeys made errors. Additionally, target match signals were highly distributed across the IT population, and while a small fraction of units reflected target matc...Continue Reading

References

Dec 1, 1991·Visual Neuroscience·J H MaunsellD D DePriest
Jan 1, 1988·Experimental Brain Research·P E HaennyP H Schiller
Sep 1, 1994·Cerebral Cortex·A LueschowR Desimone
Jan 28, 1994·Science·E K Miller, R Desimone
May 27, 1993·Nature·L ChelazziR Desimone
Oct 6, 1997·Journal of Neurophysiology·J R Gibson, J H Maunsell
Dec 24, 1998·Journal of Neurophysiology·L ChelazziR Desimone
Jul 19, 2001·Cerebral Cortex·L ChelazziR Desimone
Apr 23, 2005·Science·Narcisse P BichotRobert Desimone
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ryan E B Mruczek, David L Sheinberg
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Davide ZoccolanJames J DiCarlo
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luke Woloszyn, David L Sheinberg
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David J Freedman, John A Assad
Oct 1, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicole C Rust, James J Dicarlo
May 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tatiana A Engel, Xiao-Jing Wang
Feb 14, 2012·Neuron·James J DiCarloNicole C Rust
Feb 9, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Miriam L R MeisterAlexander C Huk
Mar 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Omri BarakStefano Fusi
Mar 12, 2013·Neuron·Chris A RishelDavid J Freedman
May 21, 2013·Nature·Mattia RigottiStefano Fusi
Jul 24, 2013·Trends in Cognitive Sciences·Nikolaus Kriegeskorte, Rogier A Kievit
Nov 10, 2013·Nature·Valerio ManteWilliam T Newsome
Jun 21, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshito KosaiAnitha Pasupathy
Aug 15, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marino Pagan, Nicole C Rust
Nov 11, 2014·Nature Neuroscience·David RaposoAnne K Churchland
Apr 14, 2016·ELife·Dmitry KobakChristian K Machens
Sep 15, 2016·Neural Computation·Marino PaganNicole C Rust

❮ Previous
Next ❯

Citations

Oct 17, 2019·Journal of Neurophysiology·Noam Roth, Nicole C Rust
Jan 6, 2021·Brain Structure & Function·Mohsen Parto DezfouliMohammad Reza Daliri
Apr 28, 2021·Proceedings of the National Academy of Sciences of the United States of America·Vahid MehrpourNicole C Rust

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation

Software Mentioned

OmniPlex
Plexon Offline Sorter
IDMS
Matlab
Brainsight

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.