Inferring action-dependent outcome representations depends on anterior but not posterior medial orbitofrontal cortex

Neurobiology of Learning and Memory
Laura A BradfieldBernard W Balleine

Abstract

Although studies examining orbitofrontal cortex (OFC) often treat it as though it were functionally homogeneous, recent evidence has questioned this assumption. Not only are the various subregions of OFC (lateral, ventral, and medial) hetereogeneous, but there is further evidence of heterogeneity within those subregions. For example, several studies in both humans and monkeys have revealed a functional subdivision along the anterior-posterior gradient of the medial OFC (mOFC). Given our previous findings suggesting that, in rats, the mOFC is responsible for inferring the likelihood of unobservable action outcomes (Bradfield, Dezfouli, van Holstein, Chieng, & Balleine, 2015), and given the anterior nature of the placements of our prior manipulations, we decided to assess whether the rat mOFC also differs in connection and function along its anteroposterior axis. We first used retrograde tracing to compare the density of efferents from mOFC to several structures known to contribute to goal-directed action: the mediodorsal thalamus, basolateral amygdala, posterior dorsomedial striatum, nucleus accumbens core and ventral tegmental area. We then compared the functional effects of anterior versus posterior mOFC excitotoxic lesions on...Continue Reading

Citations

Apr 24, 2019·ELife·Virginie FresnoMathieu Wolff
Dec 11, 2019·Journal of Neuroscience Research·Ellen P WoonShannon L Gourley
Jul 25, 2020·Neuroscience and Biobehavioral Reviews·Karly M Turner, Shauna L Parkes
Jan 11, 2019·Journal of Chemical Neuroanatomy·Juan-Carlos CerpaEtienne Coutureau
Apr 20, 2021·Current Opinion in Behavioral Sciences·Jingfeng ZhouGeoffrey Schoenbaum
Jul 24, 2021·Cerebral Cortex Communications·Cassandra MaLaura A Bradfield
Jul 24, 2021·Cerebral Cortex Communications·Alexandra MünsterWolfgang Hauber
Aug 18, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Susanne E Ahmari, Scott L Rauch
Aug 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter H Rudebeck, Alicia Izquierdo

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