Jul 22, 2018

Inferring Continuous and Discrete Population Genetic Structure Across Space

Genetics
Gideon S BradburdPeter L Ralph

Abstract

A classic problem in population genetics is the characterization of discrete population structure in the presence of continuous patterns of genetic differentiation. Especially when sampling is discontinuous, the use of clustering or assignment methods may incorrectly ascribe differentiation due to continuous processes (e.g., geographic isolation by distance) to discrete processes, such as geographic, ecological, or reproductive barriers between populations. This reflects a shortcoming of current methods for inferring and visualizing population structure when applied to genetic data deriving from geographically distributed populations. Here, we present a statistical framework for the simultaneous inference of continuous and discrete patterns of population structure. The method estimates ancestry proportions for each sample from a set of two-dimensional population layers, and, within each layer, estimates a rate at which relatedness decays with distance. This thereby explicitly addresses the "clines versus clusters" problem in modeling population genetic variation, and remedies some of the overfitting to which nonspatial models are prone. The method produces useful descriptions of structure in genetic relatedness in situations wh...Continue Reading

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Mentioned in this Paper

Genetic Drift
2-Dimensional
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Anatomical Space Structure
Cell Differentiation Process
Dental Caries
Cell Growth
Populus
Description
Structure

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