Inferring exemplar discriminability in brain representations.

PloS One
Hamed NiliNikolaus Kriegeskorte

Abstract

Representational distinctions within categories are important in all perceptual modalities and also in cognitive and motor representations. Recent pattern-information studies of brain activity have used condition-rich designs to sample the stimulus space more densely. To test whether brain response patterns discriminate among a set of stimuli (e.g. exemplars within a category) with good sensitivity, we can pool statistical evidence over all pairwise comparisons. Here we describe a wide range of statistical tests of exemplar discriminability and assess the validity (specificity) and power (sensitivity) of each test. The tests include previously used and novel, parametric and nonparametric tests, which treat subject as a random or fixed effect, and are based on different dissimilarity measures, different test statistics, and different inference procedures. We use simulated and real data to determine which tests are valid and which are most sensitive. A popular test statistic reflecting exemplar information is the exemplar discriminability index (EDI), which is defined as the average of the pattern dissimilarity estimates between different exemplars minus the average of the pattern dissimilarity estimates between repetitions of id...Continue Reading

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Citations

Jul 24, 2020·ELife·Dan BangStephen M Fleming
Apr 20, 2021·PloS One·Hamed NiliNikolaus Kriegeskorte

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