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Inferring processes underlying B-cell repertoire diversity.

bioRxiv

Feb 11, 2015

Yuval ElhanatiAleksandra M. Walczak

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Abstract

We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis captures the statistical properties of the naive repertoire, first...read more

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DNA Sequence
B-Lymphocytes
Botulinum neurotoxin A (870-1295)
Site
T-Lymphocyte
Gene Insertion
V(D)J Recombination
Lobule V
Somatic Hypermutation of Immunoglobulin Genes
Analysis
9
82
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  • Inferring processes underlying B-cell repertoire diversity.

    bioRxiv

    Feb 11, 2015

    Yuval ElhanatiAleksandra M. Walczak

    PMID: 990015115

    DOI: 10.1101/015115

    Abstract

    We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains. Our analysis captures the statistical properties of the naive repertoire, first...read more

    Mentioned in this Paper

    DNA Sequence
    B-Lymphocytes
    Botulinum neurotoxin A (870-1295)
    Site
    T-Lymphocyte
    9
    82

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