Nov 8, 2018

Inferring the direction of rhythmic neural transmission via inter-regional phase-amplitude coupling (ir-PAC)

BioRxiv : the Preprint Server for Biology
Bijurika NandiMingzhou Ding

Abstract

Phase-amplitude coupling (PAC) estimates the statistical dependence between the phase of a low-frequency and the amplitude of a high-frequency component of local field potentials (LFP). Characterizing the relationship between nested oscillations in LFPs, PAC has become a powerful tool for understanding neural dynamics in both animals and humans. In this work, we introduce a new application for this measure to two LFPs to infer the direction and strength of rhythmic neural transmission between distinct networks. Based on recently accumulating evidence that transmembrane currents related to action potentials contribute a broad-band component to LFP in the high-gamma band, we hypothesized that PAC calculated between high-gamma in one LFP and low-frequency oscillations in another would relate the output (spiking) of one area to the input (soma/dendritic postsynaptic potentials) of the other. We tested this hypothesis on theta-band long range communications between hippocampus and prefrontal cortex (PFC) and theta-band short range communications between different regions within the hippocampus. The results were interpreted within the known anatomical connections predicting hippocampus-to-PFC and DG-to-CA3-to-CA1, i.e., theta transmi...Continue Reading

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Mentioned in this Paper

Biochemical Pathway
Ca1 antibody
Clinical Study by Phase
GABRQ gene
Prefrontal Cortex
High Velocity Low Amplitude Technique
Anatomic Structures
Neuroma
Action Potentials
Synaptic Transmission

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