Infertility and miscarriage: common pathways in manifestation and management

Women's Health
Angena Agenor, Sohinee Bhattacharya

Abstract

The relationship between miscarriage and fertility is complex. While most healthcare settings treat miscarriage as a problem of subfertility in assisted reproduction units, others believe that miscarriage occurs in super-fertile women. Infertile women undergoing assisted reproduction are at a greater risk of having a miscarriage especially at an advanced age compared with women conceiving naturally. Aberrant expression of immunological factors and chromosomal abnormalities underlie both infertility and miscarriage. Common risk factors include increased maternal age, obesity, smoking, alcohol, pre-existing medical conditions and anatomical abnormalities of the reproductive system. Management pathways of both conditions may be similar with pre-implantation genetic testing and assisted reproductive technology used in both conditions. This paper discusses the synergies and differences between the two conditions in terms of their epidemiology, etiopathogenesis, risk factors and management strategies. The two conditions are related as degrees of severity of reproductive failure with common pathways in manifestation and management.

References

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Citations

Jul 20, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Emma S LucasJan J Brosens
Nov 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Samaneh Abdolmohammadi-VahidMehdi Yousefi
Jun 28, 2017·International Journal of Molecular Sciences·Dale McAninchTina Bianco-Miotto
Dec 6, 2018·Thorax·Maria Christine MagnusSiri Eldevik Håberg
Mar 22, 2019·BMJ : British Medical Journal·Maria C MagnusSiri E Håberg
Aug 28, 2019·Journal of Clinical Laboratory Analysis·Wendong HuangXiaoqiong Gu
Mar 27, 2019·Occupational and Environmental Medicine·Luise Moelenberg BegtrupJens Peter Bonde
Aug 18, 2020·International Journal of General Medicine·Hadeel Abdulelah Ibrahim
May 3, 2020·Neurology. Neuroimmunology and Neuroinflammation·Jessica B SmithAnnette Langer-Gould
May 13, 2020·American Journal of Reproductive Immunology : AJRI·Dana M SavulescuMelinda Suchard
Jul 21, 2020·Reproductive Medicine and Biology·Shuhei So, Fumiko Tawara
Jan 8, 2021·Medicina·Danielius SerapinasDaiva Bartkevičienė
May 13, 2021·Fertility and Sterility·Sara E ArianAlireza A Shamshirsaz

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Methods Mentioned

BETA
pregnancy test

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