Infertility, fertility drugs, and invasive ovarian cancer: a case-control study

Fertility and Sterility
B J MosgaardA N Andersen

Abstract

To assess the risk of invasive ovarian cancer among infertile women treated with fertility drugs. A case-control study. Nationwide data based on public registers. All Danish women (below the age of 60 years) with ovarian cancer during the period from 1989 to 1994 and twice the number of age-matched population controls. Included in the analysis were 684 cases and 1,721 controls. Influence of parity, infertility, and fertility drugs on the risk of ovarian cancer after multivariate confounder control. Risk measure(s): odds ratios (OR) with 95% confidence intervals. Nulliparous women had an increased risk of ovarian cancer compared with parous women: OR 1.5 to 2.0. Infertile, nontreated nulliparous women had an OR of 2.7 (1.3 to 5.5) compared with noninfertile nulliparous women. The OR of ovarian cancer among treated nulliparous women was 0.8 (0.4 to 2.0) and among treated parous 0.6 (0.2 to 1.3), compared with nontreated nulliparous and parous infertile women, respectively. Nulliparity implies a 1.5- to 2-fold increased risk of ovarian cancer. Infertility without medical treatment among these women increased the risk further. Among parous as well as nulliparous women, treatment with fertility drugs did not increase the ovarian can...Continue Reading

References

Jul 28, 1979·Lancet·J T CasagrandeB E Henderson
Jun 1, 1979·Gynecologic Oncology·L McGowanH J Norris
Aug 19, 1991·International Journal of Cancer. Journal International Du Cancer·E NegriD Trichopoulos
Nov 15, 1989·International Journal of Cancer. Journal International Du Cancer·H O AdamiL Bergkvist
Jul 1, 1989·American Journal of Obstetrics and Gynecology·P HartgeH J Norris
Sep 1, 1995·Acta Obstetricia Et Gynecologica Scandinavica·B MosgaardA N Andersen
May 11, 1995·The New England Journal of Medicine·G Del PrioreW R Phipps
Nov 5, 1994·Lancet·H O AdamiP O Janson
Sep 22, 1994·The New England Journal of Medicine·M A RossingS G Self

❮ Previous
Next ❯

Citations

Jul 8, 2005·Archives of Gynecology and Obstetrics·Nataki C DouglasMark V Sauer
Mar 19, 2013·Archives of Gynecology and Obstetrics·Susanne SchülerOlaf Ortmann
Jul 16, 2009·Current Treatment Options in Oncology·Thanasak Sueblinvong, Michael E Carney
Sep 15, 2004·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Jun 17, 2000·Fertility and Sterility·M MoomjyZ Rosenwaks
Apr 5, 2001·Fertility and Sterility·E S GinsburgK V Jackson
Nov 11, 2003·Fertility and Sterility·UNKNOWN Practice Committee of the American Society for Reproductive Medicine
Oct 31, 1998·Fertility and Sterility·G I SerourH Aboulghar
Dec 16, 1998·Fertility and Sterility·B J MosgaardA N Andersen
Feb 5, 1999·Obstetrics and Gynecology·B S Houmard, D B Seifer
Jul 31, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·A ShushanJ G Schenker
Mar 18, 1999·Hematology/oncology Clinics of North America·G Emons, J J Kavanagh
Apr 21, 1999·Clinical Endocrinology·T RimanS Nilsson
Mar 22, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R J Edmondson, J M Monaghan
Feb 28, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Stéphane LaframboiseB Rosen
Mar 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·L Lerner-GevaA Amit
Sep 24, 2010·American Journal of Epidemiology·M G M BraemL J Schouten
Feb 22, 2012·Human Reproduction·A-N Yli-KuhaE Hemminki
Sep 2, 1999·Journal of the National Cancer Institute·R B Ness, C Cottreau
Jun 17, 2005·Biology of Reproduction·William J Murdoch
Jun 10, 1998·Current Opinion in Obstetrics & Gynecology·K Duckitt, A A Templeton
Jan 11, 2000·Clinical Obstetrics and Gynecology·L J Wolf
May 8, 2008·Current Opinion in Obstetrics & Gynecology·Tony G ZreikAdnan R Munkarah
Apr 14, 2010·Current Opinion in Obstetrics & Gynecology·Janelle Luk, Aydin Arici
May 16, 2009·Cancer Nursing·Monica R McLemoreMarylin J Dodd
Aug 12, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C CelikC Akyürek
May 2, 2001·The Journal of Obstetrics and Gynaecology Research·V Sivanesaratnam
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·I Konishi
Feb 7, 2009·BMJ : British Medical Journal·Allan JensenSusanne Krüger Kjaer
Jun 19, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Michelle L KurtaBrenda Diergaarde
Jul 16, 2005·Gynecologic and Obstetric Investigation·Ismail OzdemirFuat Demirci
May 19, 2012·PLoS Medicine·UNKNOWN Collaborative Group on Epidemiological Studies of Ovarian Cancer
Nov 6, 2013·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Serkan YilmazSibel Erkal İlhan
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·R A KeriJ H Nilson
Oct 13, 2009·Gynécologie, obstétrique & fertilité·P MervielH Copin
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Fariba SalehiBarbara C Vanderhyden
May 2, 2008·American Journal of Epidemiology·Allan JensenSusanne Krüger Kjaer
Jan 23, 2013·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Ritsa StorengNan Birgitte Oldereid
Jun 19, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A A OdukogbeF A Oluyemi
Jun 3, 2011·Human Fertility : Journal of the British Fertility Society·Mostafa Metwally, William L Ledger
Dec 24, 2008·Psychological Reports·Aygul AkyuzUmit Göktolga

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.