Infertility in the Aging Male

Current Urology Reports
Daniel J Mazur, Larry I Lipshultz

Abstract

In many countries, the average age of paternity is rising. The negative effect of older age on fertility in women is well documented; however, less is known about the impact of paternal age on fecundity. In this review, we summarize the current knowledge of how paternal age affects semen parameters, reproductive success, and offspring health. Contemporary evidence confirms that aged men have worse semen parameters, including overall negative changes in sperm genetics. Reproductive outcomes with unassisted pregnancy tend to be worse with older fathers. While most current studies of assisted pregnancy do show a negative effect of paternal age, there are some conflicting results. Studies continue to show an overall increased risk of health problems, particularly neuropsychiatric conditions, in the offspring of older men. While men can often maintain fertility potential throughout a lifetime, increasing evidence indicates worsening of semen parameters, including sperm genetics, and potentially worse reproductive success. Older men should also be counseled on their offspring's possible increased risk of certain medical conditions.

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Citations

Feb 9, 2019·Molecular Reproduction and Development·Jianjun HuMary Ann Handel
May 16, 2019·Aging·Elena AlbaniPaolo E Levi-Setti
Sep 18, 2020·American Journal of Men's Health·Wiktoria KurkowskaAleksandra Kasperczyk
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Sep 25, 2020·Journal of Genetic Counseling·Kayla QuirinLeah Wetherill
Jan 6, 2021·The Australasian Journal of Dermatology·Dana Tzur BitanShany Sherman
Jan 23, 2021·Aging Cell·Chia-An Yen, Sean P Curran
Mar 4, 2021·Scientific Reports·Giulia CollodelElena Moretti
Aug 19, 2020·Molecular and Cellular Endocrinology·Tomer Avidor-ReissEmily Lillian Fishman
Jul 31, 2021·Journal of Assisted Reproduction and Genetics·Nicolás RamírezAna Carolina Martini

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