Infiltration of glioma cells in brain parenchyma stimulated by radiation in the F98/Fischer rat model

International Journal of Radiation Biology
Guillaume DesmaraisBenoit Paquette

Abstract

In the months following radiotherapy, a rapid recurrence of glioblastoma multiforme occurs in the periphery of the resection cavity. The aim of this study was to assess the contribution of irradiation of the brain in the infiltration profile of glioma cells. Using the F98/Fischer rat glioma model, we either irradiated the brain, the F98 cancer cells, or both to separately investigate the effects of radiation. Inflammatory cytokines and pro-infiltration molecules were measured in irradiated brain. A stimulation of interleukin-1β and transforming growth factor β1 expression 4 h after brain irradiation supported induction of inflammation. Early elevated expression of phospholipase A(2) was also measured and was followed by a stimulation of cyclooxygenase-2 from day 5 to 20 after irradiation. This resulted in a biphasic increase of prostaglandins E(2) and D(2) biosynthesis with maximum at 4 h and 15 days post-irradiation. An important enhancement of F98 cells infiltration was observed when brain was irradiated, which took place at the expense of the growth of the primary tumour and resulted in a decreased median survival of the Fischer rats. This stimulation of F98 cells infiltration was associated with the pro-infiltration molecul...Continue Reading

References

Jan 11, 1992·International Journal of Radiation Oncology, Biology, Physics·L E GasparJ G Cairncross
May 1, 1988·Journal of Neurosurgery·P C BurgerP Kleihues
Jun 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·C CooperV Walker
Jan 1, 1997·British Journal of Cancer·R R TjandrawinataM Hughes-Fulford
Apr 29, 1998·Journal of Neurology·C J Vecht
Nov 26, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S K ChintalaJ S Rao
Feb 16, 2000·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·E M GrossmannD L Kaminski
Nov 22, 2001·Journal of Neuro-oncology·W WickM Weller
Sep 13, 2002·Brain Research. Molecular Brain Research·Stephanos KyrkanidesM Kerry O'Banion
Apr 17, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A GieseM Westphal
Dec 4, 2003·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Tom B JohannesenKnut Lote
Mar 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Naoki YamanakaMitsuo Katano
Apr 20, 2004·The International Journal of Biochemistry & Cell Biology·Anita C BellailErwin G Van Meir
Jul 11, 2006·Journal of Neuro-oncology·Ilaria Tamagno, Davide Schiffer
Jun 15, 2007·Environmental Monitoring and Assessment·E Alkhatib, R Peters
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Sep 7, 2007·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·David MathieuDavid Fortin
Dec 19, 2007·Cancer Metastasis Reviews·Douglas M NoonanAdriana Albini
Jan 17, 2008·Neuroscience and Behavioral Physiology·A V Gilyarov
Apr 9, 2008·Critical Reviews in Oncology/hematology·Alba A BrandesCharles Vecht
May 22, 2008·Neurochemical Research·Paola Dell'Albani
Sep 25, 2008·Neurosurgery·Mitchel S Berger, Costas G Hadjipanayis
Feb 13, 2010·International Journal of Radiation Biology·Won Hee LeeYong Woo Lee
Apr 7, 2010·Expert Review of Neurotherapeutics·Annunziato MangiolaPasquale De Bonis
Apr 29, 2010·Brain Tumor Pathology·Ryuhei KitaiKen-Ichiro Kikuta
Oct 22, 2010·Current Opinion in Neurology·Patrick RothMichael Weller
Jan 15, 2011·International Journal of Radiation Biology·Rosalie LemayBenoit Paquette

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Citations

Jun 21, 2015·Journal of Neuroscience Methods·Timo Kirschstein, Rüdiger Köhling
May 7, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Laure BobykHélène Elleaume
Mar 30, 2016·Cellular and Molecular Life Sciences : CMLS·Marta VilaltaEdward E Graves
Aug 15, 2015·Investigational New Drugs·Laurent-Olivier RoyDavid Fortin
Apr 29, 2015·International Journal of Radiation Biology·Guillaume DesmaraisBenoit Paquette
Aug 10, 2013·Radiation Research·Benoit PaquetteJ Richard Wagner
Mar 5, 2014·Targeted Oncology·Laurent-Olivier RoyDavid Fortin
Jul 10, 2014·Journal of Cancer Research and Clinical Oncology·Wei ZhouZhenyu Shao
Apr 29, 2016·International Journal of Radiation Biology·Guillaume DesmaraisBenoit Paquette
Mar 2, 2018·NMR in Biomedicine·Amanda M HamiltonPaula J Foster
Oct 22, 2016·Neuro-oncology·Philippe MeneiJean Michel Lemée
Apr 13, 2018·International Journal of Molecular Sciences·Laurent-Olivier RoyDavid Fortin
Apr 12, 2019·EJNMMI Research·Thititip TippayamontriLéon Sanche
Mar 18, 2020·Brain Structure & Function·Davy Charles VanderweyenDavid Fortin
Apr 23, 2020·Cellular Signalling·Joanna L BirchGareth J Inman
May 21, 2021·Frontiers in Cell and Developmental Biology·Rachel N Curry, Stacey M Glasgow
Jul 16, 2021·International Journal of Radiation Biology·Ayman Oweida, Benoit Paquette

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