Infiltrative nature of tumor-induced osteomalacia lesions in bone: Correlation between radiological and histopathological features

Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association
Hiroshi KobayashiSakae Tanaka

Abstract

Tumor-induced osteomalacia is a rare paraneoplastic syndrome usually caused by phosphaturic mesenchymal tumors, which commonly occur in bone. This study aimed to investigate the radiological features of tumor-induced osteomalacia lesions in bone, and their correlation with its histopathology. This study included 13 patients with tumor-induced osteomalacia treated between January 2000 and April 2018 at our hospital. All patients were surveyed to detect the tumor causing the condition. Diagnostic imaging studies of the suspected tumors were obtained before tumor removal. We evaluated the radiological features of all tumors, investigated histopathological findings in 10 cases that underwent surgery, and obtained evaluable tumor specimens. The tumors were classified into the following three types by CT: sclerotic (n = 4), lytic (n = 7), and mixed (n = 2). In two cases, lytic lesions focally invaded the surrounding cancellous bone, detected by the soft tissue-window of CT, not the bone-window. Histopathology revealed inter-trabecular invasion in all cases, regardless of radiological features. Osteoclasts were seen in lytic types, and creeping substitution-like thickened trabecular bone and calcification were observed in sclerotic ty...Continue Reading

Citations

Aug 17, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Hiroshi KobayashiSakae Tanaka

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