"Inflammaging" and bone in the OsteoLaus cohort

Immunity & Ageing : I & a
Jessica FischerBérengère Aubry-Rozier

Abstract

"Inflammaging" is a coined term that combines the processes of inflammation (within the normal range) and aging, since chronic, low-grade, systemic inflammation emerges with increasing age. Unlike high-level inflammation, with which deleterious effects on bone no longer need to be demonstrated, it is unclear whether inflammaging exerts deleterious effects on bone too. We assessed associations between inflammaging - measured via cytokine levels (high-sensitivity C-reactive protein (hs-CRP); interleukin-1β (IL-1β); interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α)) - and bone parameters (prevalent and incident fractures, bone mineral density (BMD) and trabecular bone score (TBS)) in 1390 postmenopausal women from the OsteoLaus study. Mean (±SD) age was 64.5 ± 7.6 and mean bone mass index (BMI) 25.9 ± 4.5 kg/m2. Median hs-CRP, IL-1β, IL-6 and TNF-α were 1.4 pg/ml, 0.57 pg/ml, 2.36 pg/ml and 4.82 pg/ml, respectively. In total, 10.50% of the participants had a prevalent, low-impact fracture; and, after 5-years of follow up, 5.91% had an incident, low-impact fracture. Mean T-score BMD was - 1.09 ± 1.53 for the spine, - 1.08 ± 1.02 for the femoral neck, and - 0.72 ± 0.96 for the total hip. Mean spine TBS was 1.320 ± 0.10. We fo...Continue Reading

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Citations

Sep 10, 2020·Clinical Reviews in Bone and Mineral Metabolism·Gianmaria SalvioGilberta Giacchetti
Mar 2, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Jacob S GriffinSteph M Berger
May 2, 2021·Journal of Orthopaedic Surgery and Research·Virginia Veronica ViscontiUmberto Tarantino

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

OsteoLaus
HK Genant
Stata

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