'Inflammaging' refers to the chronic, low-grade inflammation that characterizes aging. Inflammaging is macrophage centered, involves several tissues and organs, including the gut microbiota, and is characterized by a complex balance between pro- and anti-inflammatory responses. Based on literature data, we argue that the major source of inflammatory stimuli is represented by endogenous/self, misplaced, or altered molecules resulting from damaged and/or dead cells and organelles (cell debris), recognized by receptors of the innate immune system. While their production is physiological and increases with age, their disposal by the proteasome via autophagy and/or mitophagy progressively declines. This 'autoreactive/autoimmune' process fuels the onset or progression of chronic diseases that can accelerate and propagate the aging process locally and systemically. Consequently, inflammaging can be considered a major target for antiaging strategies.
Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans
Ceramide as a TLR4 agonist; a putative signalling intermediate between sphingolipid receptors for microbial ligands and TLR4
Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis
Role of systemic inflammatory response in predicting survival in patients with primary operable cancer
Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: the Vitality 90+ study
Inflamm-aging of the stem cell niche: breast cancer as a paradigmatic example: breakdown of the multi-shell cytokine network fuels cancer in aged people
Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases
The interaction of HspA1A with TLR2 and TLR4 in the response of neutrophils induced by ovarian cancer cells in vitro.
The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection
Age-related differences in the expression of circulating microRNAs: miR-21 as a new circulating marker of inflammaging
Characterization of the role of distinct plasma cell-free DNA species in age-associated inflammation and frailty
Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation
Endoplasmic reticulum stress is sufficient for the induction of IL-1β production via activation of the NF-κB and inflammasome pathways
Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer.
Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for "inflamm-aging"
Both genetic and dietary factors underlie individual differences in DNA damage levels and DNA repair capacity
Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers
Proteasome activation: An innovative promising approach for delaying aging and retarding age-related diseases
Overexpression of the microRNA miR-433 promotes resistance to paclitaxel through the induction of cellular senescence in ovarian cancer cells
Characterization of Skin Aging-Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin
Associations of circulating plasma microRNAs with age, body mass index and sex in a population-based study
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors
Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes
Centenarians as a 21st century healthy aging model: A legacy of humanity and the need for a world-wide consortium (WWC100+)
When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies
Dexmedetomidine Prevents Cognitive Decline by Enhancing Resolution of High Mobility Group Box 1 Protein-induced Inflammation through a Vagomimetic Action in Mice
Disparate Habitual Physical Activity and Dietary Intake Profiles of Elderly Men with Low and Elevated Systemic Inflammation
The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects
Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?
Mesenchymal stromal cells from human umbilical cord prevent the development of lung fibrosis in immunocompetent mice
A genetics-based approach confirms immune associations with life history across multiple populations of an aquatic vertebrate (Gasterosteus aculeatus)
90th Anniversary Commentary: ω-3 Fatty Acids, Cytokines, and Lymphocyte Proliferation in Young and Older Women
Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study
Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting
Serum Retinol but Not 25(OH)D Status Is Associated With Serum Hepcidin Levels in Older Mexican Adults
Illegitimate and Repeated Genomic Integration of Cell-Free Chromatin in the Aetiology of Somatic Mosaicism, Ageing, Chronic Diseases and Cancer
Integrating the "Immunome" in the Stratification of Myelodysplastic Syndromes and Future Clinical Trial Design.
The smell of longevity: a combination of Volatile Organic Compounds (VOCs) can discriminate centenarians and their offspring from age-matched subjects and young controls.
Anti-aging Effects of Calorie Restriction (CR) and CR Mimetics based on the Senoinflammation Concept
Network topology dynamics of circulating biomarkers and cognitive performance in older Cytomegalovirus-seropositive or -seronegative men and women
High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential.
Integrative analysis of gut microbiota composition, host colonic gene expression and intraluminal metabolites in aging C57BL/6J mice
Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice
The mitomiR/Bcl-2 axis affects mitochondrial function and autophagic vacuole formation in senescent endothelial cells
Relationships between markers of inflammation and bone density: findings from the Hertfordshire Cohort Study
Association of lifestyle factors and inflammation with sarcopenic obesity: data from the PREDIMED-Plus trial
The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging
Differential Markov random field analysis with an application to detecting differential microbial community networks
Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2
Intrinsic Type 1 Interferon (IFN1) Profile of Uncultured Human Bone Marrow CD45low CD271+ Multipotential Stromal Cells (BM-MSCs): The Impact of Donor Age, Culture Expansion and IFNα and IFNβ Stimulation
Convergent adaptation of cellular machineries in the evolution of large body masses and long life spans
Age-Related Macular Degeneration: A Connection between Human Herpes Virus-6A-Induced CD46 Downregulation and Complement Activation?
Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis
Occurrence and Dynamism of Lactic Acid Bacteria in Distinct Ecological Niches: A Multifaceted Functional Health Perspective
Vitamin K as a Powerful Micronutrient in Aging and Age-Related Diseases: Pros and Cons from Clinical Studies
A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
Vitamin C and E Treatment Blunts Sprint Interval Training-Induced Changes in Inflammatory Mediator-, Calcium-, and Mitochondria-Related Signaling in Recreationally Active Elderly Humans
Immunobiography and the Heterogeneity of Immune Responses in the Elderly: A Focus on Inflammaging and Trained Immunity
Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?
ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective
Inflammation as a Modulator of Host Susceptibility to Pulmonary Influenza, Pneumococcal, and Co-Infections.
Remodeling of the Immune Response With Aging: Immunosenescence and Its Potential Impact on COVID-19 Immune Response
Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study.
Ecological Sensing Through Taste and Chemosensation Mediates Inflammation: A Biological Anthropological Approach.
Circulating BPIFB4 Levels Associate With and Influence the Abundance of Reparative Monocytes and Macrophages in Long Living Individuals.
Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies
The potential of non-myeloablative heterochronous autologous hematopoietic stem cell transplantation for extending a healthy life span
Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications
The Modulatory Effect of Gender and Cytomegalovirus-Seropositivity on Circulating Inflammatory Factors and Cognitive Performance in Elderly Individuals
Examining Relationships between Metabolism and Persistent Inflammation in HIV Patients on Antiretroviral Therapy
Macrophage Immunometabolism and Inflammaging: Roles of Mitochondrial Dysfunction, Cellular Senescence, CD38, and NAD
Longitudinal comparative transcriptomics reveals unique mechanisms underlying extended healthspan in bats
Exercise-Induced Regulation of Redox Status in Cardiovascular Diseases: The Role of Exercise Training and Detraining
Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age.
Brain aging and garbage cleaning : Modelling the role of sleep, glymphatic system, and microglia senescence in the propagation of inflammaging.
The association between change of soluble tumor necrosis factor receptor R1 (sTNF-R1) measurements and cardiovascular and all-cause mortality-Results from the population-based (Cardiovascular Disease, Living and Ageing in Halle) CARLA study 2002-2016
Age-related susceptibility to coronavirus infections: role of impaired and dysregulated host immunity
Horticultural Therapy Reduces Biomarkers of Immunosenescence and Inflammaging in Community-Dwelling Older Adults: A Feasibility Pilot Randomized Controlled Trial
Crosstalk between Long-Term Sublethal Oxidative Stress and Detrimental Inflammation as Potential Drivers for Age-Related Retinal Degeneration.
Cytokine signature of inflammation mediated by autoreactive Th-cells, in calf muscle of claudicating patients with Fontaine stage II peripheral artery disease.
A geroscience approach for Parkinson's disease: Conceptual framework and design of PROPAG-AGEING project.
Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease.
Inflammaging as a common ground for the development and maintenance of sarcopenia, obesity, cardiomyopathy and dysbiosis
Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling.
The complex relationship between Immunosenescence and Inflammaging: Special issue on the New Biomedical Perspectives
The "Elderly" Lesson in a "Stressful" Life: Italian Holistic Approach to Increase COVID-19 Prevention and Awareness
Aging induces B cell defects and decreased antibody responses to influenza infection and vaccination
ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis
The preventive strategy for pandemics in the elderly is to collect in advance samples & data to counteract chronic inflammation (inflammaging)
60 Years of clonal hematopoiesis research: From X-chromosome inactivation studies to the identification of driver mutations
Alterations of monocyte NF-κB p65/RelA signaling in a cohort of older medical patients, age-matched controls, and healthy young adults.
Combination of curcumin and luteolin synergistically inhibits TNF-α-induced vascular inflammation in human vascular cells and mice
Obesity, malnutrition, and trace element deficiency in the coronavirus disease (COVID-19) pandemic: An overview.
Therapeutic Potential for Regulation of the Nuclear Factor Kappa-B Transcription Factor p65 to Prevent Cellular Senescence and Activation of Pro-Inflammatory in Mesenchymal Stem Cells.
RNA-Seq analysis reveals critical transcriptome changes caused by sodium butyrate in DN mouse models.
The Role of Inflammation and Infection in Age-Related Neurodegenerative Diseases: Lessons From Bacterial Meningitis Applied to Alzheimer Disease and Age-Related Macular Degeneration.
Multi-omics reveals age-related differences in the diaphragm response to mechanical ventilation: a pilot study.
The multifaceted roles of macrophages in bone regeneration: A story of polarization, activation and time.
Aging-Associated Metabolic Disorders
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Genetics & Epigenetics of Aging
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Aging Genetics (Keystone)
This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.
Autophagy & Model Organisms
Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms
Cell Aging (Keystone)
This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.
Autophagy & Disease
Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.
Cancer Epigenetics & Metabolism (Keystone)
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This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.
A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here
Autophagy & Metabolism
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