Inflammaging impairs peripheral nerve maintenance and regeneration

Aging Cell
Robert BüttnerHelen Morrison

Abstract

The regenerative capacity of peripheral nerves declines during aging, contributing to the development of neuropathies, limiting organism function. Changes in Schwann cells prompt failures in instructing maintenance and regeneration of aging nerves; molecular mechanisms of which have yet to be delineated. Here, we identified an altered inflammatory environment leading to a defective Schwann cell response, as an underlying mechanism of impaired nerve regeneration during aging. Chronic inflammation was detected in intact uninjured old nerves, characterized by increased macrophage infiltration and raised levels of monocyte chemoattractant protein 1 (MCP1) and CC chemokine ligand 11 (CCL11). Schwann cells in the old nerves appeared partially dedifferentiated, accompanied by an activated repair program independent of injury. Upon sciatic nerve injury, an initial delayed immune response was followed by a persistent hyperinflammatory state accompanied by a diminished repair process. As a contributing factor to nerve aging, we showed that CCL11 interfered with Schwann cell differentiation in vitro and in vivo. Our results indicate that increased infiltration of macrophages and inflammatory signals diminish regenerative capacity of aging...Continue Reading

References

Oct 1, 1976·Laboratory Animals·C RowlattM U Sheriff
Jun 25, 1996·Biochemical and Biophysical Research Communications·J L GaoA D Luster
Jan 11, 2001·Journal of the Peripheral Nervous System : JPNS·E VerdúX Navarro
Feb 15, 2002·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·N KatoK Fujikawa
Jun 17, 2004·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Keith Fenrich, Tessa Gordon
Jul 9, 2004·The EMBO Journal·Marie C HarrisinghAlison C Lloyd
Nov 23, 2006·Mechanisms of Ageing and Development·Claudio FranceschiStefano Salvioli
Mar 8, 2007·Annual Review of Neuroscience·Zu-Lin ChenSidney Strickland
May 24, 2007·Journal of Neurotrauma·Yong-Jun WangTian-Fang Li
Nov 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Audrey BoivinSteve Lacroix
May 21, 2008·The Journal of Cell Biology·David B ParkinsonKristján R Jessen
May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Satish L DeshmaneBassel E Sawaya
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thea MorrisDerek W Gilroy
Aug 18, 2009·International Review of Neurobiology·Uros KovacicFajko F Bajrović
Jul 30, 2010·Current Opinion in Immunology·Albert C ShawJanet M Lord
Oct 4, 2011·The Journal of Clinical Investigation·Chi Him Eddie MaClifford J Woolf
Sep 18, 2012·Biomaterials·Nassir MokarramRavi V Bellamkonda
Feb 13, 2013·Journal of Neurochemistry·George Harauz, Joan M Boggs
Mar 5, 2013·The Journal of Clinical Investigation·Encarnacion Montecino-RodriguezKenneth Dorshkind
Oct 3, 2013·International Review of Neurobiology·Petr DubovýTomas Kubek
Dec 18, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hyuno Kang, Jeff W Lichtman
Apr 22, 2014·Journal of Visualized Experiments : JoVE·Alexander SchulzReinhard Bauer
Oct 24, 2014·Frontiers in Immunology·Guillermo Arango Duque, Albert Descoteaux
Apr 29, 2015·Mediators of Inflammation·Bruno Siqueira MiettoAna Maria Blanco Martinez
May 10, 2015·Cold Spring Harbor Perspectives in Biology·Kristján R JessenAlison C Lloyd
May 30, 2016·Acta Neuropathologica·Alexander SchulzHelen Morrison

❮ Previous
Next ❯

Citations

Sep 13, 2019·International Journal of Molecular Sciences·Li ZuoTingyang Zhou
Jun 22, 2020·American Journal of Reproductive Immunology : AJRI·Peihao LiuYingying Qin
Aug 15, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Rong HuangGurpreet S Baht
Aug 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wenzheng XiaShiting Li
Apr 25, 2019·International Journal of Molecular Sciences·Alan V Nguyen, Athena M Soulika
Mar 1, 2019·Annals of Geriatric Medicine and Research·Sun-Hyung KimJae-Young Lim
Jan 18, 2020·Mediators of Inflammation·Lulingxiao NieQi Wang
Feb 12, 2021·Frontiers in Molecular Neuroscience·Anjali BalakrishnanCarol Schuurmans
Feb 16, 2021·Frontiers in Aging Neuroscience·Kathleen M Hagen, Shalina S Ousman
Jun 4, 2020·Ageing Research Reviews·Sophie VanhunselLieve Moons
Mar 24, 2021·Journal of Neuroinflammation·Kathleen M Hagen, Shalina S Ousman
Apr 25, 2021·Journal of Neuroimmunology·Kathleen M Hagen, Shalina S Ousman
Aug 17, 2020·Mechanisms of Ageing and Development·Leopold BöhmHelen Morrison
Apr 18, 2021·Developmental Neurobiology·Patricia J WardArthur W English
Jun 24, 2021·Proceedings of the National Academy of Sciences of the United States of America·Annelies VennekensHugo Vankelecom
Apr 6, 2021·Aging and Disease·Sandra Fuertes-Alvarez, Ander Izeta
Feb 3, 2022·Cellular and Molecular Neurobiology·Ana Carolina Correa de AssisRenato Nery Soriano

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

PANTHER Enrichment
ImageJ

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Related Papers

Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
Wan-shan WangYing-jie Piao
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Pallavi SinghGretchen J Darlington
Zhonghua wai ke za zhi [Chinese journal of surgery]
Tao HuangDayong Liu
© 2022 Meta ULC. All rights reserved